Claim

Model ledger-default@0.1.0 ledger-strict@0.1.0 ledger-default@0.2.0 ledger-strict@0.2.0 ledger-default@0.3.0 (default) ledger-strict@0.3.0 Snapshot seq

Topics

Not filed under any topic yet.

Assessment

Why?

Strongest counted support: The same report gives the combined assay’s 86.8% stage I–II sensitivity in the testing cohort. weight 1.800000 evidence

Review gaps: qualifiers reviewed, opposing search done, independence reviewed

What would most change this: One independent, direct measurement that contradicts this claim would move it from Supported to Supported.

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Checked as part of

Statements this claim was broken out of. The claim is scored on its own; a statement's reading only counts its claims.

• “The reported PANXEON sensitivity and false-positive rates were measured in a testing cohort containing separate low-risk and high-risk control groups.” · 1 claim · 28 September 2026

Evidence for

• The Nature Medicine abstract directly states the testing-cohort scope and separate low- and high-risk control groups.

  From Liquid biopsy for early detection of pancreatic ductal adenocarcinoma Read 2026-09-29 Relevance DIRECT Steps 0 Counted

  Direct evidence for the new narrowed quantitative claim.

• Independent reporting explicitly distinguishes low-risk and high-risk control groups and gives their separate PANXEON false-positive rates.

  From PANXEON Blood Test Detects Early Pancreatic Cancer Read 2026-09-28 Relevance DIRECT Steps 0 Counted

• The same report gives the combined assay’s 86.8% stage I–II sensitivity in the testing cohort.

  From PANXEON Blood Test Detects Early Pancreatic Cancer Read 2026-09-28 Relevance DIRECT Steps 0 Counted

Evidence against

None.

Qualifications

• The report identifies the results as research-cohort performance rather than evidence of population-screening mortality benefit.

  From PANXEON Blood Test Detects Early Pancreatic Cancer Read 2026-09-28 Relevance MODERATE Steps 1 Counted

Suppressed as dependent

None.

Inferences

Concluded from

None.

Used as a premise in

None.

An inference is interpretation, not evidence: it never changes the assessment of its conclusion. Each premise is a claim with its own evidence.

Threads

None. Threads are for disagreements about how a determination was made — a statement whose figures are not in the passage it rests on, two sources that may share an origin. Something about the world belongs in the evidence above.

Claim edges

From	Relationship	To
68c78451	NARROWS	ff28a421

Review checklist

Review checks: 1 of 4

2 checks by this claim's own author, alongside the independent review above. 1 OPPOSING EVIDENCE SEARCH · 1 QUALIFIER CHECK. A check by the person who recorded a claim does not raise its review coverage.

Check	Done	By
qualifiers reviewed	no
opposing search done	no
independence reviewed	no
primary source reviewed	yes	325e0295

Summary

Contribution history

seq	event	detail
14215	APPENDED
14216	ACCEPT	AUTOMATIC_AFTER_VALIDATION
14224	LINK_EVIDENCE	by 1efd24fe (accepted)
14273	TASK_RESULT	by 1efd24fe (accepted)

Score trace

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  "claim": "e3563849-0001-824d-889e-6e5e68c78451",
  "links": [
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      "direction": "SUPPORT",
      "magnitude": "1.800000",
      "relevance": "DIRECT",
      "extraction": "UNVERIFIED",
      "provenance": "INDEPENDENT",
      "observation": "DIRECT_TEXT",
      "source_type": "SECONDARY_TEXT",
      "authenticity": "UNVERIFIED",
      "audit_confirmed": false,
      "effective_weight": "1.800000",
      "interpretive_steps": 0
    },
    {
      "link": "8cda3b31-9c5e-8dca-baba-052a325e0295",
      "group": null,
      "edition": "NAMED_OR_UNRELATED",
      "evidence": "c4c6ab6d-0505-8252-88e0-cba79a1d2b4a",
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      "magnitude": "1.800000",
      "relevance": "DIRECT",
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      "source_type": "PRIMARY_TEXT",
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    },
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      "group": null,
      "reason": "non_directional",
      "edition": "NAMED_OR_UNRELATED",
      "evidence": "f7720acc-d992-883b-96bb-9044320b2f3d",
      "direction": "QUALIFY",
      "magnitude": "0.459000",
      "relevance": "MODERATE",
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    },
    {
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      "interpretive_steps": 0
    }
  ],
  "model": "ledger-default@0.3.0",
  "prior": "0.50",
  "variants": {
    "spread": "0.0214",
    "permissive": "0.9991",
    "conservative": "0.9777"
  },
  "code_hash": "sha256:c61a6fdf35a754a0d7e958df149036a083c0eaeb7d2d2e52704ec32b0c36def7",
  "contested": false,
  "stability": "HIGH",
  "claim_type": "QUANTITATIVE",
  "config_hash": "sha256:86768038080b8ab5233f1e4b7aba10af05b5bb44caa432095150b90e81209809",
  "probability": "0.9955",
  "provisional": true,
  "evidence_sum": "5.400000",
  "snapshot_seq": 14274,
  "prior_log_odds": "0.000000",
  "support_groups": 3,
  "model_dependent": false,
  "review_coverage": "0.25",
  "truth_evaluable": true,
  "assessment_state": "SUPPORTED",
  "review_checklist": {
    "qualifiers_reviewed": {
      "by": [],
      "ok": false
    },
    "opposing_search_done": {
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    },
    "independence_reviewed": {
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      "ok": false
    },
    "primary_source_reviewed": {
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        "8cda3b31-9c5e-8dca-baba-052a325e0295"
      ],
      "ok": true
    }
  },
  "contradict_groups": 0,
  "rounding_boundary": false,
  "posterior_log_odds": "5.400000",
  "not_applicable_reason": null,
  "independence_unreviewed": 4
}