Claims
| Claim | Type | Assessment | Score | Review checks | References |
|---|---|---|---|---|---|
| In experimental renal fibrosis, SRPX2 interacted with IRP1 and disrupted iron-regulatory signaling, and iron dextran supplementation alleviated UUO-induced renal fibrosis. | CAUSAL | Supported | 0.9601 | 1 of 4 | 103 |
| SRPX2 expression was elevated in CKD patient kidney and serum samples and in experimental renal-fibrosis models, while global or tubular-epithelial deletion of Srpx2 attenuated kidney injury and fibrosis in mice. | CAUSAL | Supported | 0.9601 | 1 of 4 | 107 |