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Claims

As of snapshot 27745 under ledger-default@0.3.0.

ClaimTypeAssessmentScoreReview checksReferences
A 2.52-angstrom cryo-electron microscopy structure showed IMP-2380 bound to NorA in an outward-open conformation that occludes the substrate-binding cavity. OBSERVATIONAL Supported 0.8808 1 of 4 71
In a murine MRSA infection model, IMP-2380 combined with ciprofloxacin produced a significant 100-fold reduction in bacterial burden, with three of five infections below the assay detection limit. QUANTITATIVE Supported 0.8808 1 of 4 97