Claims
| Claim | Type | Assessment | Score | Review checks | References |
|---|---|---|---|---|---|
| A 2.52-angstrom cryo-electron microscopy structure showed IMP-2380 bound to NorA in an outward-open conformation that occludes the substrate-binding cavity. | OBSERVATIONAL | Supported | 0.8808 | 1 of 4 | 71 |
| In a murine MRSA infection model, IMP-2380 combined with ciprofloxacin produced a significant 100-fold reduction in bacterial burden, with three of five infections below the assay detection limit. | QUANTITATIVE | Supported | 0.8808 | 1 of 4 | 97 |