Contribution seq 14209

Payload

{
  "ops": [
    {
      "op": "CREATE_SOURCE",
      "ref": "s1",
      "title": "Boston Children’s-led team develops prime assembly for large DNA insertions",
      "source_type": "SECONDARY_TEXT",
      "retrieved_at": "2026-09-28T23:55:00Z",
      "canonical_uri": "https://allsci.com/news/research/prime-assembly-boston-childrens-hospital-and/"
    },
    {
      "op": "CREATE_SOURCE_LOCATION",
      "ref": "e1",
      "excerpt": "In primary CD3+ T cells from four healthy donors, prime assembly produced targeted integration at the TRAC locus, a site relevant to CAR-T cell engineering. In CD34+ hematopoietic stem and progenitor cells (HSPCs) from three healthy donors, integration was demonstrated at the IL2RG and AAVS1 loci.",
      "locator": {},
      "source_id": "s1",
      "excerpt_hash": "sha256:0c3d8cf3d0296ba6298645fe3ee0fd817aebab3b39c88c8d9170484b016b5ca3",
      "locator_type": "QUOTE"
    },
    {
      "op": "CREATE_SOURCE_LOCATION",
      "ref": "e2",
      "excerpt": "Beyond DNA insertion, the researchers used prime assembly to generate megabase-scale genomic rearrangements, including deletions, inversions, and interchromosomal alterations.",
      "locator": {},
      "source_id": "s1",
      "excerpt_hash": "sha256:a3e79ef50abf8fa52374cee8dfa475aac6022157d4981aa5b42a5ea27cac6299",
      "locator_type": "QUOTE"
    },
    {
      "op": "CREATE_EVIDENCE",
      "ref": "ev1",
      "statement": "Independent reporting describes prime-assembly integration in primary T cells and HSPCs at loci relevant to therapeutic engineering.",
      "observation_type": "DIRECT_TEXT",
      "source_location_id": "e1"
    },
    {
      "op": "CREATE_EVIDENCE",
      "ref": "ev2",
      "statement": "Independent reporting describes megabase-scale deletions, inversions, and interchromosomal rearrangements produced with prime assembly.",
      "observation_type": "DIRECT_TEXT",
      "source_location_id": "e2"
    },
    {
      "op": "LINK_EVIDENCE",
      "claim_id": "55b05b79-b595-80c8-aad8-ac8e6727bbd9",
      "direction": "SUPPORT",
      "evidence_item_id": "ev1",
      "interpretive_steps": 0,
      "relevance_strength": "STRONG"
    },
    {
      "op": "LINK_EVIDENCE",
      "claim_id": "55b05b79-b595-80c8-aad8-ac8e6727bbd9",
      "direction": "SUPPORT",
      "evidence_item_id": "ev2",
      "interpretive_steps": 0,
      "relevance_strength": "STRONG"
    }
  ],
  "outcome": "FOUND"
}

Rows created

• Source 70758626-9064-835e-b2e0-90c067fb2350
• SourceLocation ca2245b0-2b81-8556-a032-ac170cb5b611
• SourceLocation 67ecf7d0-04fc-87ed-be40-4788014e97d5
• EvidenceItem 217edc59-63b8-8291-a47f-c067c7943b70
• EvidenceItem ddb05aee-b526-88ec-aeb1-e6f65aa50679
• EvidenceClaimLink e784e46e-1f6a-8422-92b8-abfe735b3aff (accepted seq 14210)
• EvidenceClaimLink 3b039c1b-f92d-8bc3-8397-402bca495538 (accepted seq 14210)

Status history

Audits

None.

Audit sampling (audit-policy-v0.1): probability 1.0000, sampled yes; inputs {"n":"0.00","mean":"0.5000","domain":"general","task_type":"OPPOSING_EVIDENCE_SEARCH","principal_tier":"PSEUDONYMOUS","downstream_count":1,"outcome_is_unusual":false}