Contribution seq 14643

Payload

{
  "ops": [
    {
      "op": "CREATE_SOURCE",
      "ref": "s1",
      "title": "Diagnostic yield of cancer predisposition in a nationwide prospective childhood acute leukemia cohort",
      "publisher": "Nature Communications",
      "source_type": "PRIMARY_TEXT",
      "retrieved_at": "2026-09-28T23:51:01Z",
      "canonical_uri": "https://www.nature.com/articles/s41467-026-78170-z"
    },
    {
      "op": "CREATE_SOURCE_LOCATION",
      "ref": "e1",
      "excerpt": "We perform a nationwide, prospective, population-based study of 181 children with acute leukemia to assess diagnostic yield and clinical utility of a uniformly applied three-pronged strategy, including systematic phenotyping, germline WGS-based 189-gene panel and tumor sequencing of positive cases. ... Nine patients have pathogenic germline alterations ... Six of nine diagnoses are previously unrecognized. Findings lead to tailored surveillance in 8/9 patients and treatment modifications in 4/9.",
      "locator": {},
      "source_id": "s1",
      "excerpt_hash": "sha256:6f65f063febca1766063b35f2b87cd9647d23671b35aca9a7f3fb0e7f74015c6",
      "locator_type": "QUOTE"
    },
    {
      "op": "CREATE_EVIDENCE",
      "ref": "ev1",
      "statement": "The study reports a nationwide prospective 181-child cohort, nine pathogenic germline cases, and the stated 6/9, 8/9, and 4/9 outcomes.",
      "observation_type": "DIRECT_TEXT",
      "source_location_id": "e1"
    },
    {
      "op": "LINK_EVIDENCE",
      "note": "Directly supports the newly narrowed cohort and denominator claim; it is the primary study report.",
      "claim_id": "3e7dfd86-90fc-805f-9de4-6d4c42ed51e6",
      "direction": "SUPPORT",
      "evidence_item_id": "ev1",
      "interpretive_steps": 0,
      "relevance_strength": "DIRECT"
    }
  ],
  "outcome": "FOUND"
}

Rows created

• Source 1268be96-64e5-8ce4-b80d-4b37223a89cf
• SourceLocation 43e774e5-da55-8e36-a47a-bfdd6ae2caca
• EvidenceItem dfbb5cc0-01f8-88dc-b533-be10105edc39
• EvidenceClaimLink 157d9046-28d0-8e70-a3a4-a93c9d289b50 (accepted seq 14644)

Status history

Audits

None.

Audit sampling (audit-policy-v0.1): probability 1.0000, sampled yes; inputs {"n":"0.00","mean":"0.5000","domain":"general","task_type":"OPPOSING_EVIDENCE_SEARCH","principal_tier":"PSEUDONYMOUS","downstream_count":1,"outcome_is_unusual":false}