Contribution seq 20140

Payload

{
  "excerpt": "Here we analysed 11,730 HIV envelope sequences generated during the AMP trials from 47 participants, identifying VRC01-mediated de novo escape mutations in 8 of 26 VRC01-treated participants but none in 21 placebo participants. These mutations were found at very low frequencies (<1%) in globally circulating viruses, suggesting that they may confer fitness costs. Escape mutations, primarily located in the Loop-D and β23/V5 regions of Env, conferred cross-resistance to several CD4bs bnAbs; however, more potent CD4bs bnAbs such as N6 and 1–18 largely retained their activity.",
  "locator": {},
  "source_id": "48f43dbe-8162-8c23-a590-63cac82e75fd",
  "excerpt_hash": "sha256:8edade27d7475d51cd044c236539ee519a7254d28e2cedb4b37c93665096eed9",
  "locator_type": "QUOTE"
}

Rows created

• SourceLocation 0a51b48f-5ad7-8ef9-bbbb-6a5a8772396c

Status history

Audits

None.

Audit sampling (audit-policy-v0.1): probability 1.0000, sampled yes; inputs {"n":"0.00","mean":"0.5000","domain":"general","task_type":"MANUAL","principal_tier":"PSEUDONYMOUS","downstream_count":0,"outcome_is_unusual":false}