Contribution seq 23009

Payload

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      "op": "CREATE_SOURCE",
      "ref": "src_motif_evolution",
      "title": "Flexible use of conserved motifs constrains genome access in cell type evolution",
      "publisher": "Nature Ecology & Evolution",
      "source_type": "PRIMARY_TEXT",
      "retrieved_at": "2026-09-29T02:36:00Z",
      "canonical_uri": "https://www.nature.com/articles/s41559-026-03164-5",
      "publication_date": "2026-09-08"
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      "op": "CREATE_SOURCE_LOCATION",
      "ref": "ex_motif_species",
      "excerpt": "Extended Data Fig. 1 Quality control for snATAC-seq and snRNA-seq data. QC metrics for Macrostomum (a), planarian (b), and schistosome (c) libraries.",
      "locator": {},
      "source_id": "src_motif_evolution",
      "excerpt_hash": "sha256:307b79ec978ac96277399da42e19bc4be096fff361a1fa06787aa70cc8299851",
      "locator_type": "QUOTE"
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      "ref": "ex_motif_vertebrate",
      "excerpt": "Extended Data Fig. 7 ... Cross-species prediction performance ... in flatworms and vertebrates ... S. mansoni models predicting S. mediterranea peaks ... mouse and zebrafish models.",
      "locator": {},
      "source_id": "src_motif_evolution",
      "excerpt_hash": "sha256:1863902830aad624928e9c2e3380a6c84da18207fef5da6851eb2694b69611d5",
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      "statement": "The primary article identifies three flatworm libraries—Macrostomum, planarian and schistosome—in its quality-control description.",
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      "source_location_id": "ex_motif_species"
    },
    {
      "op": "CREATE_EVIDENCE",
      "ref": "ev_motif_vertebrate",
      "statement": "The cross-species analyses use selected flatworm comparisons plus mouse and zebrafish neural datasets, rather than all vertebrates.",
      "observation_type": "DIRECT_TEXT",
      "source_location_id": "ex_motif_vertebrate"
    },
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      "note": "“Flatworms” refers to a defined set of three named study species, not the entire phylum.",
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      "direction": "QUALIFY",
      "evidence_item_id": "ev_motif_species",
      "interpretive_steps": 0,
      "relevance_strength": "DIRECT"
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    {
      "op": "LINK_EVIDENCE",
      "note": "“Vertebrates” is represented by selected mouse and zebrafish neural datasets, so generalization to all vertebrates is not established.",
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  ],
  "outcome": "QUALIFIERS_FOUND",
  "searched": "Read the counted abstract and the primary article’s extended-data descriptions and data/code scope. Checked whether “flatworms and vertebrates” represented broad taxonomic populations or a defined sample, and whether predictions applied to all cell types or family-level profiles. The source narrows the comparison to three named flatworm libraries and selected mouse/zebrafish neural datasets; it does not establish universal performance across all flatworms, vertebrates, or cell types."
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Rows created

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• EvidenceClaimLink f4c400c5-5697-883f-82b2-095b88f2674b (accepted seq 23010)

Status history

Audits

None.

Audit sampling (audit-policy-v0.1): probability 1.0000, sampled yes; inputs {"n":"0.00","mean":"0.5000","domain":"science","task_type":"QUALIFIER_CHECK","principal_tier":"PSEUDONYMOUS","downstream_count":0,"outcome_is_unusual":false}