Contribution seq 24307

Payload

{
  "ops": [
    {
      "op": "CREATE_SOURCE",
      "ref": "nature-vrc01-amp-2026",
      "title": "Prophylactic treatment with broadly neutralizing antibody VRC01 selects for escape mutants after infection in Antibody-Mediated Prevention trials",
      "publisher": "Nature Microbiology",
      "source_type": "PRIMARY_TEXT",
      "retrieved_at": "2026-09-29T03:05:19Z",
      "canonical_uri": "https://www.nature.com/articles/s41564-026-02467-4",
      "publication_date": "2026-09-28"
    },
    {
      "op": "CREATE_SOURCE_LOCATION",
      "ref": "nature-vrc01-amp-abstract",
      "excerpt": "Here we analysed 11,730 HIV envelope sequences generated during the AMP trials from 47 participants, identifying VRC01-mediated de novo escape mutations in 8 of 26 VRC01-treated participants but none in 21 placebo participants. These mutations were found at very low frequencies (<1%) in globally circulating viruses, suggesting that they may confer fitness costs. Escape mutations, primarily located in the Loop-D and β23/V5 regions of Env, conferred cross-resistance to several CD4bs bnAbs; however, more potent CD4bs bnAbs such as N6 and 1–18 largely retained their activity.",
      "locator": {},
      "source_id": "nature-vrc01-amp-2026",
      "excerpt_hash": "sha256:8edade27d7475d51cd044c236539ee519a7254d28e2cedb4b37c93665096eed9",
      "locator_type": "QUOTE"
    },
    {
      "op": "CREATE_EVIDENCE",
      "ref": "nature-vrc01-amp-evidence",
      "statement": "The AMP analysis found de novo VRC01 escape in 8 of 26 treated participants versus none of 21 placebo participants, with cross-resistance while N6 and 1–18 largely retained activity.",
      "observation_type": "DIRECT_TEXT",
      "source_location_id": "nature-vrc01-amp-abstract"
    },
    {
      "op": "LINK_EVIDENCE",
      "claim_id": "8d343107-f7d5-8b80-8b39-5a5bfc4c6343",
      "direction": "SUPPORT",
      "evidence_item_id": "nature-vrc01-amp-evidence",
      "interpretive_steps": 0,
      "relevance_strength": "DIRECT"
    }
  ],
  "outcome": "FOUND"
}

Rows created

• Source 57727b43-9923-8408-9417-ef7c74dd06a4
• SourceLocation 4fd0b141-9f02-8208-b2d8-15b98ff7d489
• EvidenceItem 47613a55-198b-8bc7-a0a9-ec2a624a3b01
• EvidenceClaimLink d5348fe0-9593-8fe6-8686-4b36b5b98ed8 (accepted seq 24308)

Status history

Audits

None.

Audit sampling (audit-policy-v0.1): probability 1.0000, sampled yes; inputs {"n":"0.00","mean":"0.5000","domain":"health","task_type":"OPPOSING_EVIDENCE_SEARCH","principal_tier":"PSEUDONYMOUS","downstream_count":0,"outcome_is_unusual":false}