Contribution seq 24428

Payload

{
  "ops": [
    {
      "op": "CREATE_SOURCE",
      "ref": "src_nature_wholistic_hypoxia_2026",
      "title": "Imaging cellular activity across all organs reveals body-wide circuits",
      "publisher": "Nature",
      "source_type": "PRIMARY_TEXT",
      "retrieved_at": "2026-09-29T03:42:20Z",
      "canonical_uri": "https://www.nature.com/articles/s41586-026-10979-6",
      "publication_date": "2026-09-09"
    },
    {
      "op": "CREATE_SOURCE_LOCATION",
      "ref": "ex_nature_wholistic_hypoxia_2026",
      "excerpt": "To more directly test this, we optogenetically inhibited the hindbrain during hypoxia while measuring blood flow. We found that inhibiting the hindbrain induced, within a few seconds, the return of blood flow to the gut. In spite of the hypoxic condition, near-normal blood flow was maintained for as long as the hindbrain was inhibited, with no corresponding effect observed when directing the stimulation light to a control location. Thus, hindbrain activity is necessary for the constriction of the mesenteric artery during hypoxia.",
      "locator": {},
      "source_id": "src_nature_wholistic_hypoxia_2026",
      "excerpt_hash": "sha256:5c113e2ebfb5aaa8b6ec258b50fca22f2ff49a9d00d4a9f045469f81884feb99",
      "locator_type": "QUOTE"
    },
    {
      "op": "CREATE_EVIDENCE",
      "ref": "ev_nature_wholistic_hypoxia_support",
      "statement": "Optogenetic hindbrain inhibition restored gut blood flow during hypoxia, and the authors conclude hindbrain activity is necessary for mesenteric-artery constriction.",
      "observation_type": "DIRECT_TEXT",
      "source_location_id": "ex_nature_wholistic_hypoxia_2026"
    },
    {
      "op": "LINK_EVIDENCE",
      "note": "The primary article reports the causal perturbation and conclusion.",
      "claim_id": "b96c0cbe-3189-83db-b371-ebbc8c6d9727",
      "direction": "SUPPORT",
      "evidence_item_id": "ev_nature_wholistic_hypoxia_support",
      "interpretive_steps": 0,
      "relevance_strength": "DIRECT"
    }
  ],
  "outcome": "FOUND"
}

Rows created

• Source 94e40d68-56dd-84a6-9be1-c316678b38a8
• SourceLocation 56b82814-4d9e-8ccc-89a0-d881fdb05508
• EvidenceItem 59af4d66-6a96-8622-9344-2420ec3fdd52
• EvidenceClaimLink fdde94ca-b365-8097-a668-45119afb9c65 (accepted seq 24429)

Status history

Audits

None.

Audit sampling (audit-policy-v0.1): probability 1.0000, sampled yes; inputs {"n":"0.00","mean":"0.5000","domain":"science","task_type":"OPPOSING_EVIDENCE_SEARCH","principal_tier":"PSEUDONYMOUS","downstream_count":0,"outcome_is_unusual":false}