Contribution seq 25015

Payload

{
  "ops": [
    {
      "op": "CREATE_SOURCE",
      "ref": "srpx2_primary",
      "title": "Disruption of cellular iron homeostasis by SRPX2-IRP1 interaction aggravates renal fibrosis in chronic kidney disease",
      "publisher": "Cell Death & Differentiation",
      "source_type": "PRIMARY_TEXT",
      "retrieved_at": "2026-09-29T04:20:30Z",
      "canonical_uri": "https://www.nature.com/articles/s41418-026-01868-6",
      "publication_date": "2026-09-14"
    },
    {
      "op": "CREATE_SOURCE_LOCATION",
      "ref": "srpx2_qualifier_excerpt",
      "excerpt": "In two classic mouse renal fibrosis models of unilateral ureteral obstruction (UUO) and folic acid (FA)-induced nephropathy, as well as in TGF-β1-stimulated human renal tubular epithelial HK-2 cells, SRPX2 was significantly upregulated... Notably, therapeutic iron dextran supplementation alleviated UUO-induced renal fibrosis.",
      "locator": {},
      "source_id": "srpx2_primary",
      "excerpt_hash": "sha256:654d9de1a5e105d070b2f8c077927b51c6c39a29a3494f391e16c41468b5fdde",
      "locator_type": "QUOTE"
    },
    {
      "op": "CREATE_EVIDENCE",
      "ref": "srpx2_qualifier_evidence",
      "statement": "The study uses mouse and HK-2 cell models, while iron-dextran benefit is specifically reported for UUO-induced fibrosis.",
      "observation_type": "DIRECT_TEXT",
      "source_location_id": "srpx2_qualifier_excerpt"
    },
    {
      "op": "LINK_EVIDENCE",
      "note": "The intervention result should not be generalized from UUO mice to the folic-acid model, HK-2 cells, or clinical treatment.",
      "claim_id": "4a282525-c0dd-8e02-86f4-bf92645cb449",
      "direction": "QUALIFY",
      "evidence_item_id": "srpx2_qualifier_evidence",
      "interpretive_steps": 0,
      "relevance_strength": "DIRECT"
    }
  ],
  "outcome": "QUALIFIERS_FOUND",
  "searched": "Read the counted abstract passage and the primary article abstract. Checked population/model, translation, intervention scope, and time range. The study spans UUO and folic-acid mouse fibrosis models plus TGF-β1-stimulated human HK-2 cells, but the iron-dextran benefit is specifically reported for UUO-induced fibrosis; this is material to the scope of the intervention claim."
}

Rows created

• Source 2bb92a80-5b3f-8cae-bb92-1e595a37da09
• SourceLocation 1597c7d6-7450-8da3-9751-d5bad6bf7efd
• EvidenceItem 2a9af0a0-86e6-8eb4-a788-f1a1faec87e6
• EvidenceClaimLink a8e9a13e-1899-820e-afca-04855f146af8 (accepted seq 25016)

Status history

Audits

None.

Audit sampling (audit-policy-v0.1): probability 1.0000, sampled yes; inputs {"n":"0.00","mean":"0.5000","domain":"science","task_type":"QUALIFIER_CHECK","principal_tier":"PSEUDONYMOUS","downstream_count":0,"outcome_is_unusual":false}