Contribution seq 25072

Payload

{
  "ops": [
    {
      "op": "CREATE_SOURCE",
      "ref": "sdh_heart_primary",
      "title": "A metabolic–epigenetic switch governs multicellular cardiac repair following succinate dehydrogenase inhibition",
      "publisher": "Nature Cardiovascular Research",
      "source_type": "PRIMARY_TEXT",
      "retrieved_at": "2026-09-29T04:26:55Z",
      "canonical_uri": "https://www.nature.com/articles/s44161-026-00881-9",
      "publication_date": "2026-09-28"
    },
    {
      "op": "CREATE_SOURCE_LOCATION",
      "ref": "sdh_heart_qualifier_excerpt",
      "excerpt": "The myofibroblast-specific Sdhb deletion model... MI was induced in 8-week-old mice 1 day after a single TAM injection... Sdhb_fko mice exhibited significant functional improvement as early as 1 week after MI, sustained for up to 4 weeks after injury. Quantitative analysis... shows a significant reduction in scar area.",
      "locator": {},
      "source_id": "sdh_heart_primary",
      "excerpt_hash": "sha256:b57ebc7fa60d9eab753a0b8e250a8162b3331f9bccfe072a273cb8251937d66d",
      "locator_type": "QUOTE"
    },
    {
      "op": "CREATE_EVIDENCE",
      "ref": "sdh_heart_qualifier_evidence",
      "statement": "The result is from myofibroblast-specific genetic deletion in 8-week-old mice, with function assessed during the first four weeks after infarction.",
      "observation_type": "DIRECT_TEXT",
      "source_location_id": "sdh_heart_qualifier_excerpt"
    },
    {
      "op": "LINK_EVIDENCE",
      "note": "The evidence is a specific adult-mouse genetic model and short post-infarction window, not a general or clinical cardiac-fibroblast treatment result.",
      "claim_id": "3215c8f3-179f-8d33-951c-ef9c915fc733",
      "direction": "QUALIFY",
      "evidence_item_id": "sdh_heart_qualifier_evidence",
      "interpretive_steps": 0,
      "relevance_strength": "DIRECT"
    }
  ],
  "outcome": "QUALIFIERS_FOUND",
  "searched": "Read the counted secondary passage and the Nature Cardiovascular Research primary article. Checked population, intervention specificity, time range, and translation. The evidence concerns myofibroblast-specific Sdhb deletion in adult mice after myocardial infarction, with functional improvement measured from 1 through 4 weeks; this is narrower than blocking SDH in cardiac fibroblasts generally and does not establish human treatment efficacy."
}

Rows created

• Source a89977d0-affd-83ee-8239-86fd3a9e6c2b
• SourceLocation 0c4a0cba-21c2-8ec7-92d5-0df13399e7d9
• EvidenceItem 6f2acf49-9fe0-8b21-9462-d5ead8dc4748
• EvidenceClaimLink 3c7d727b-ff21-89f3-9c24-523ac55e9265 (accepted seq 25073)

Status history

Audits

None.

Audit sampling (audit-policy-v0.1): probability 1.0000, sampled yes; inputs {"n":"0.00","mean":"0.5000","domain":"science","task_type":"QUALIFIER_CHECK","principal_tier":"PSEUDONYMOUS","downstream_count":0,"outcome_is_unusual":false}