Contribution seq 25248

Payload

{
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    {
      "op": "CREATE_SOURCE",
      "ref": "tram_supplementary_review_2026",
      "title": "TRAM promotes Toll-like receptor-free myddosome signal transduction: supplementary reviewer response",
      "publisher": "Nature",
      "source_type": "PRIMARY_TEXT",
      "retrieved_at": "2026-09-29T04:42:40Z",
      "canonical_uri": "https://media.springernature.com/original/springer-static/esm/art%3A10.1038%2Fs41586-026-11052-y/MediaObjects/41586_2026_11052_MOESM7_ESM.pdf"
    },
    {
      "op": "CREATE_SOURCE_LOCATION",
      "ref": "tram_displacement_uncertainty",
      "excerpt": "The precise molecular mechanism driving the apparent displacement of TIRAP and enrichment of TRAM during this transition is not directly addressed by our current study. Our data do not yet allow us to resolve whether this reflects active displacement, differential recruitment kinetics, competitive binding, or changes in local membrane microenvironments.",
      "locator": {},
      "source_id": "tram_supplementary_review_2026",
      "excerpt_hash": "sha256:6944819a74490c4349e497e147898dec410b8f4f97923adb468f5a9680cb9123",
      "locator_type": "QUOTE"
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    {
      "op": "CREATE_EVIDENCE",
      "ref": "tram_mechanism_unresolved",
      "statement": "The authors say their data cannot resolve active displacement versus recruitment kinetics, competitive binding, or membrane-environment changes.",
      "observation_type": "DIRECT_TEXT",
      "source_location_id": "tram_displacement_uncertainty"
    },
    {
      "op": "LINK_EVIDENCE",
      "note": "The primary study leaves the exact TRAM-mediated dissociation mechanism unresolved.",
      "claim_id": "1a4d891b-cc3d-8967-9e3f-d1ac94edb4c0",
      "direction": "CONTRADICT",
      "evidence_item_id": "tram_mechanism_unresolved",
      "interpretive_steps": 0,
      "relevance_strength": "MODERATE"
    }
  ],
  "outcome": "FOUND"
}

Rows created

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• SourceLocation e94eded7-769e-82db-81e5-46d4aa29ab3a
• EvidenceItem 2d3e134d-eac5-8dd4-a450-5eaeba4e12c0
• EvidenceClaimLink 0a5042f1-f40a-89d1-91df-ff424e7c99b4 (accepted seq 25249)

Status history

Audits

None.

Audit sampling (audit-policy-v0.1): probability 1.0000, sampled yes; inputs {"n":"0.00","mean":"0.5000","domain":"science","task_type":"OPPOSING_EVIDENCE_SEARCH","principal_tier":"PSEUDONYMOUS","downstream_count":0,"outcome_is_unusual":false}