Contribution seq 25318

Payload

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      "op": "CREATE_SOURCE",
      "ref": "rio_naturemedicine",
      "title": "Broadly neutralizing antibodies in adult males living with HIV undergoing analytical treatment interruption: secondary and exploratory outcomes of the phase II randomized controlled RIO trial",
      "source_type": "PRIMARY_TEXT",
      "retrieved_at": "2026-09-29T04:55:12Z",
      "canonical_uri": "https://www.nature.com/articles/s41591-026-04644-8"
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      "excerpt": "Sixty-eight adult men living with human immunodeficiency virus (HIV), who were predominantly white and initiated antiretroviral therapy (ART) during primary or early-stage infection, underwent treatment interruption and were randomly assigned to a group receiving one or two doses of two long-acting broadly neutralizing antibodies (bNAbs) 3BNC117-LS and 10-1074-LS (arm A, n = 34) or saline (arm B, n = 34).",
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      "locator_type": "QUOTE"
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      "ref": "rio_reservoir_excerpt",
      "excerpt": "To determine how the bNAbs impact the size of the proviral reservoir in arm A, we compared the intact and defective proviral reservoirs at baseline with prerebound samples collected at a mean of 52 weeks after the initial infusion (n = 22; Fig. 6 and Supplementary Table 1). ... Although there was a great deal of variation between individuals in arm A over time, the intact reservoir but not the defective one was significantly smaller after bNAb therapy with an estimated half-life of 36 weeks (n = 22).",
      "locator": {},
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      "locator_type": "QUOTE"
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      "ref": "rio_limitations_excerpt",
      "excerpt": "Therefore, these associations are correlative and based on a limited number of individuals, but the observed reservoir decay is suggestive of altered reservoir dynamics in this cohort of PLWH undergoing ATI under LS-bNAb exposure.",
      "locator": {},
      "source_id": "rio_naturemedicine",
      "excerpt_hash": "sha256:1cc088bb8e4e2e95dd89103934398c55aa465597c9101d6b9d011b9383462d8b",
      "locator_type": "QUOTE"
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    {
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      "ref": "rio_population_evidence",
      "statement": "The 68-person cohort comprised predominantly white men who began ART during primary or early-stage HIV infection.",
      "observation_type": "DIRECT_TEXT",
      "source_location_id": "rio_population_excerpt"
    },
    {
      "op": "CREATE_EVIDENCE",
      "ref": "rio_reservoir_evidence",
      "statement": "The reservoir decline was measured in 22 antibody-arm participants at a mean of 52 weeks, and only intact—not defective—proviruses declined.",
      "observation_type": "MEASUREMENT",
      "source_location_id": "rio_reservoir_excerpt"
    },
    {
      "op": "CREATE_EVIDENCE",
      "ref": "rio_limitations_evidence",
      "statement": "The reservoir association is correlative and based on a limited number of individuals under specific long-acting antibody exposure.",
      "observation_type": "EXPERT_ANALYSIS",
      "source_location_id": "rio_limitations_excerpt"
    },
    {
      "op": "LINK_EVIDENCE",
      "note": "Adds early-treatment and demographic scope.",
      "claim_id": "48e36fc0-52e3-80ab-8a44-4ad71304f296",
      "direction": "QUALIFY",
      "evidence_item_id": "rio_population_evidence",
      "interpretive_steps": 0,
      "relevance_strength": "DIRECT"
    },
    {
      "op": "LINK_EVIDENCE",
      "note": "Bounds the reservoir result to paired antibody-arm samples at a defined follow-up and distinguishes intact from defective proviruses.",
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    },
    {
      "op": "LINK_EVIDENCE",
      "note": "Records the authors' limitation that the reservoir association is correlative and sample-limited.",
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  ],
  "outcome": "QUALIFIERS_FOUND",
  "searched": "Read the counted rebound passage and the Nature Medicine primary report. Checked time range, population, denominator, baseline, sampling, jurisdiction, and endpoint definitions. The cohort was predominantly white men treated during primary/early infection, and the reservoir decline was a paired ddPCR analysis of 22 antibody-arm participants; the report states the association is correlative and limited by peripheral-blood sampling."
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Status history

Audits

None.

Audit sampling (audit-policy-v0.1): probability 1.0000, sampled yes; inputs {"n":"0.00","mean":"0.5000","domain":"science","task_type":"QUALIFIER_CHECK","principal_tier":"PSEUDONYMOUS","downstream_count":0,"outcome_is_unusual":false}