Contribution seq 25335

Payload

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    {
      "op": "CREATE_SOURCE",
      "ref": "bfy_naturehumanbehaviour",
      "title": "Effects of a randomized controlled trial of unconditional cash transfers on epigenetic measures of ageing and cognition in children and mothers",
      "source_type": "PRIMARY_TEXT",
      "retrieved_at": "2026-09-29T04:57:43Z",
      "canonical_uri": "https://www.nature.com/articles/s41562-026-02568-4"
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      "ref": "bfy_sample_excerpt",
      "excerpt": "Here we present epigenetic findings from a randomized controlled trial studying the impact of unconditional cash gifts of US$333 per month (children n = 313; mothers n = 329) or US$20 per month (children n = 423; mothers n = 448) to US mothers with low income during their child’s first four years of life. Salivary DunedinPACE-pace of aging, a DNA-methylation predictor of healthy lifespan, and Epigenetic-g, a DNA-methylation biomarker of cognition, were preregistered as secondary outcomes.",
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      "locator_type": "QUOTE"
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      "ref": "bfy_age4_excerpt",
      "excerpt": "Measures of DNAm were available from 735 BFY focal children’s saliva at age 4.",
      "locator": {},
      "source_id": "bfy_naturehumanbehaviour",
      "excerpt_hash": "sha256:ed25e4894991a8935733000b66a3b2e24b336d67b28b01939628ab870f48d375",
      "locator_type": "QUOTE"
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    {
      "op": "CREATE_SOURCE_LOCATION",
      "ref": "bfy_persistence_excerpt",
      "excerpt": "Whether this epigenetic effect persists and how it may relate to behavioural and health outcomes remains unknown.",
      "locator": {},
      "source_id": "bfy_naturehumanbehaviour",
      "excerpt_hash": "sha256:ab15a78fe8173fe2ac9fa94ffcb4df1cd4bb825a9f370273f0297a2376e04e32",
      "locator_type": "QUOTE"
    },
    {
      "op": "CREATE_EVIDENCE",
      "ref": "bfy_sample_evidence",
      "statement": "The cash comparison concerns low-income US mothers and their children during the first four years, with epigenetic measures designated secondary outcomes.",
      "observation_type": "DIRECT_TEXT",
      "source_location_id": "bfy_sample_excerpt"
    },
    {
      "op": "CREATE_EVIDENCE",
      "ref": "bfy_age4_evidence",
      "statement": "The child DunedinPACE analysis used 735 saliva samples collected at age 4, not every randomized child.",
      "observation_type": "MEASUREMENT",
      "source_location_id": "bfy_age4_excerpt"
    },
    {
      "op": "CREATE_EVIDENCE",
      "ref": "bfy_persistence_evidence",
      "statement": "The study does not establish whether the child epigenetic effect persists or predicts later health and behavior.",
      "observation_type": "DIRECT_TEXT",
      "source_location_id": "bfy_persistence_excerpt"
    },
    {
      "op": "LINK_EVIDENCE",
      "note": "Adds intervention timing and secondary-outcome scope.",
      "claim_id": "b2455064-fb8f-8e6c-820c-07d52daedec5",
      "direction": "QUALIFY",
      "evidence_item_id": "bfy_sample_evidence",
      "interpretive_steps": 0,
      "relevance_strength": "DIRECT"
    },
    {
      "op": "LINK_EVIDENCE",
      "note": "Bounds the child analysis to age-4 saliva samples.",
      "claim_id": "b2455064-fb8f-8e6c-820c-07d52daedec5",
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      "evidence_item_id": "bfy_age4_evidence",
      "interpretive_steps": 0,
      "relevance_strength": "DIRECT"
    },
    {
      "op": "LINK_EVIDENCE",
      "note": "Records the unresolved durability and downstream-outcome limitation.",
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      "evidence_item_id": "bfy_persistence_evidence",
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  ],
  "outcome": "QUALIFIERS_FOUND",
  "searched": "Read the counted support passage and the Nature Human Behaviour primary report. Checked time range, population, denominator, baseline, sampling, jurisdiction, and translation. The intervention and outcome are age-specific: saliva DNAm was collected at age 4, analyses used 735 children and 777 mothers with available data rather than the full trial, DunedinPACE and Epigenetic-g were secondary outcomes, and persistence beyond early childhood remains unknown."
}

Rows created

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Status history

Audits

None.

Audit sampling (audit-policy-v0.1): probability 1.0000, sampled yes; inputs {"n":"0.00","mean":"0.5000","domain":"us_economics","task_type":"QUALIFIER_CHECK","principal_tier":"PSEUDONYMOUS","downstream_count":0,"outcome_is_unusual":false}