Contribution seq 25342

Payload

{
  "ops": [
    {
      "op": "CREATE_SOURCE",
      "ref": "nipt_naturecommunications",
      "title": "Embryo selection by non-invasive preimplantation genetic testing for aneuploidy in women of advanced maternal age: a randomized, clinical trial",
      "source_type": "PRIMARY_TEXT",
      "retrieved_at": "2026-09-29T04:58:18Z",
      "canonical_uri": "https://www.nature.com/articles/s41467-026-77628-4"
    },
    {
      "op": "CREATE_SOURCE_LOCATION",
      "ref": "nipt_scope_excerpt",
      "excerpt": "In this investigator-initiated, multicenter, double-blind, randomised controlled trial, women aged 35-42 who agreed to single frozen-thawed blastocyst transfer with at least two blastocysts were enrolled from 13 fertility centers in China. Eligible participants were randomly assigned (1:1) to the niPGT-A (n = 594) or morphology group (n = 595). The primary outcome was the ongoing pregnancy rate (OPR) (pregnancy beyond 12 weeks). The modified intention-to-treat population contained 581 couples in the morphology group and 571 in the niPGT-A group.",
      "locator": {},
      "source_id": "nipt_naturecommunications",
      "excerpt_hash": "sha256:8b9dabf23bcee39954f140cd9bf1e804a7c4bc3637e88c1127a3ddec4d5209e6",
      "locator_type": "QUOTE"
    },
    {
      "op": "CREATE_EVIDENCE",
      "ref": "nipt_scope_evidence",
      "statement": "The null OPR result applies to good-prognosis patients with at least two blastocysts receiving one frozen-thawed transfer; OPR means pregnancy beyond 12 weeks.",
      "observation_type": "DIRECT_TEXT",
      "source_location_id": "nipt_scope_excerpt"
    },
    {
      "op": "LINK_EVIDENCE",
      "note": "Adds eligibility, endpoint definition, and modified-intention-to-treat scope.",
      "claim_id": "699f5d54-2a9f-8939-a2be-022894031d50",
      "direction": "QUALIFY",
      "evidence_item_id": "nipt_scope_evidence",
      "interpretive_steps": 0,
      "relevance_strength": "DIRECT"
    }
  ],
  "outcome": "QUALIFIERS_FOUND",
  "searched": "Read the counted primary passage and the Nature Communications report. Checked time range, population, denominator, baseline, sampling, jurisdiction, and endpoint definition. The result applies to good-prognosis women aged 35–42 with at least two blastocysts undergoing a single frozen-thawed transfer; ongoing pregnancy means beyond 12 weeks, and the reported mITT denominators were 571 and 581 rather than the full randomized groups."
}

Rows created

• Source 0e5065b2-d284-818b-9a28-bb651d5e4d60
• SourceLocation 727fdd28-3cfe-871e-8e83-be4627363605
• EvidenceItem ef583cda-f06a-8bea-93ab-6cac85d9b247
• EvidenceClaimLink 590f086e-e847-8ea4-80b6-caff7b573cb6 (accepted seq 25343)

Status history

Audits

None.

Audit sampling (audit-policy-v0.1): probability 1.0000, sampled yes; inputs {"n":"0.00","mean":"0.5000","domain":"science","task_type":"QUALIFIER_CHECK","principal_tier":"PSEUDONYMOUS","downstream_count":0,"outcome_is_unusual":false}