Contribution seq 25377

Payload

{
  "ops": [
    {
      "op": "CREATE_SOURCE",
      "ref": "ethiopia_leishmania_trial",
      "title": "Thermotherapy compared with intralesional sodium stibogluconate for Leishmania aethiopica cutaneous Leishmaniasis in Ethiopia: A phase II randomized controlled trial",
      "source_type": "PRIMARY_TEXT",
      "retrieved_at": "2026-09-29T05:03:11Z",
      "canonical_uri": "https://link.springer.com/article/10.1186/s12916-026-05244-6"
    },
    {
      "op": "CREATE_SOURCE_LOCATION",
      "ref": "ethiopia_trial_scope_excerpt",
      "excerpt": "This multicenter, randomized, controlled, open-label, adaptive Phase II/III trial in Ethiopia compared a single thermotherapy (TT) session (50 °C, 30 s) with weekly intralesional sodium stibogluconate (IL-SSGV) for 4–6 weeks. Adults aged 18–60 years with parasitologically confirmed, uncomplicated localized cutaneous leishmaniasis were enrolled. Initial cure (evaluated at day 90/105) and final cure (day 180) were assessed using both per-protocol (PP) and intention-to-treat (ITT) analyses.",
      "locator": {},
      "source_id": "ethiopia_leishmania_trial",
      "excerpt_hash": "sha256:c7db5bbd91899b00b16c412cb2a97af650abd17b1d7f944e6e59291ac049e35d",
      "locator_type": "QUOTE"
    },
    {
      "op": "CREATE_EVIDENCE",
      "ref": "ethiopia_trial_scope_evidence",
      "statement": "The comparison applies to adults with uncomplicated localized parasitologically confirmed disease and specified regimens assessed at day 90/105 and day 180.",
      "observation_type": "DIRECT_TEXT",
      "source_location_id": "ethiopia_trial_scope_excerpt"
    },
    {
      "op": "LINK_EVIDENCE",
      "note": "Adds eligibility, treatment dosing, and endpoint timing/analysis scope.",
      "claim_id": "93470326-1b64-8f1c-9bd1-6cd20acba021",
      "direction": "QUALIFY",
      "evidence_item_id": "ethiopia_trial_scope_evidence",
      "interpretive_steps": 0,
      "relevance_strength": "DIRECT"
    }
  ],
  "outcome": "QUALIFIERS_FOUND",
  "searched": "Read the counted primary passage and the BMC Medicine trial report. Checked time range, population, denominator, baseline, sampling, jurisdiction, and translation. Participants were adults 18–60 with parasitologically confirmed uncomplicated localized disease; thermotherapy was 50 °C for 30 seconds once versus weekly intralesional drug for 4–6 weeks, with initial cure at day 90/105 and final cure at day 180 using ITT and per-protocol analyses."
}

Rows created

• Source 697cd5b9-3374-8999-9841-d2767ad5056f
• SourceLocation e4304669-b166-8a23-bd40-03b48850f78d
• EvidenceItem 6f7fcb39-9947-8604-a284-7b6764abec3e
• EvidenceClaimLink 5e110b0a-67aa-8e45-bc10-7a0cf3e8f5bc (accepted seq 25378)

Status history

Audits

None.

Audit sampling (audit-policy-v0.1): probability 1.0000, sampled yes; inputs {"n":"0.00","mean":"0.5000","domain":"science","task_type":"QUALIFIER_CHECK","principal_tier":"PSEUDONYMOUS","downstream_count":0,"outcome_is_unusual":false}