Contribution seq 25461

Payload

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      "op": "CREATE_SOURCE",
      "ref": "psychad_atlas_primary_20260929",
      "title": "Single-nucleus atlas of cell-type specific genetic regulation in the human brain",
      "publisher": "Nature Genetics",
      "source_type": "PRIMARY_TEXT",
      "retrieved_at": "2026-09-29T05:32:00Z",
      "canonical_uri": "https://www.nature.com/articles/s41588-026-02733-5",
      "publication_date": "2026-09-23"
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    {
      "op": "CREATE_SOURCE_LOCATION",
      "ref": "atlas_sampling",
      "excerpt": "In this work, we collected 5.6 million nuclei from the human dorsolateral prefrontal cortex (DLPFC) of a genetically diverse set of 1,384 donors from the full PsychAD dataset, 35.6% of whom are of non-European ancestry.",
      "locator": {},
      "source_id": "psychad_atlas_primary_20260929",
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      "locator_type": "QUOTE"
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      "op": "CREATE_SOURCE_LOCATION",
      "ref": "atlas_qc",
      "excerpt": "Brain tissue from the DLPFC was obtained from 1,494 donors by the PsychAD Consortium... A total of 1,384 donors with genotype data and snRNA-seq data passing quality control were analyzed in this study.",
      "locator": {},
      "source_id": "psychad_atlas_primary_20260929",
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      "locator_type": "QUOTE"
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    {
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      "ref": "atlas_sampling_limits",
      "excerpt": "The number of detected eGenes increases with cell type abundance... Further stratification into 27 cell subclasses enhances cellular resolution but often reduces statistical power relative to class-level analyses because of decreased sample sizes within each subclass.",
      "locator": {},
      "source_id": "psychad_atlas_primary_20260929",
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      "locator_type": "QUOTE"
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    {
      "op": "CREATE_SOURCE_LOCATION",
      "ref": "atlas_age",
      "excerpt": "The cohort includes similar numbers of males and females and spans the entire postnatal age range of 0 to 108 years.",
      "locator": {},
      "source_id": "psychad_atlas_primary_20260929",
      "excerpt_hash": "sha256:797e6a79ee897131c4f04d1695677e2c79359458685407d7fe9f49c4d9e74b2c",
      "locator_type": "QUOTE"
    },
    {
      "op": "CREATE_CLAIM",
      "ref": "psychad_atlas_scope_qualifier",
      "claim_type": "QUANTITATIVE",
      "qualifiers": {},
      "canonical_text": "The atlas analyzed postmortem dorsolateral prefrontal-cortex tissue from 1,384 PsychAD donors passing genotype and snRNA-seq quality control, including 493 non-European-ancestry donors (35.6%) across ages 0–108; its 14,258 gene-regulation findings are eGenes detected through multi-resolution eQTL analysis, with detection varying by cell-type abundance and subclass sample size.",
      "affirms_not_private_individual": true
    },
    {
      "op": "CREATE_CLAIM_EDGE",
      "to_claim_id": "fcaf50f5-e520-8368-8686-6911ddba5235",
      "from_claim_id": "psychad_atlas_scope_qualifier",
      "relationship_type": "NARROWS"
    },
    {
      "op": "CREATE_EVIDENCE",
      "ref": "ev_atlas_sampling",
      "statement": "The dataset is postmortem human dorsolateral prefrontal cortex, with 5.6 million nuclei from 1,384 diverse-ancestry donors and 35.6% non-European ancestry.",
      "observation_type": "DATASET_RESULT",
      "source_location_id": "atlas_sampling"
    },
    {
      "op": "CREATE_EVIDENCE",
      "ref": "ev_atlas_qc",
      "statement": "The analyzed 1,384 donors are the QC-passing subset of 1,494 DLPFC donors initially obtained.",
      "observation_type": "DATASET_RESULT",
      "source_location_id": "atlas_qc"
    },
    {
      "op": "CREATE_EVIDENCE",
      "ref": "ev_atlas_limits",
      "statement": "eGene detection depends on cell-type abundance, and subclass resolution can reduce power because of smaller subclass sample sizes.",
      "observation_type": "DIRECT_TEXT",
      "source_location_id": "atlas_sampling_limits"
    },
    {
      "op": "CREATE_EVIDENCE",
      "ref": "ev_atlas_age",
      "statement": "The donor cohort spans the full postnatal age range from 0 to 108 years with similar male and female counts.",
      "observation_type": "DATASET_RESULT",
      "source_location_id": "atlas_age"
    },
    {
      "op": "LINK_EVIDENCE",
      "note": "Specifies the exact brain region, postmortem sampling, donor count, and ancestry proportion.",
      "claim_id": "fcaf50f5-e520-8368-8686-6911ddba5235",
      "direction": "QUALIFY",
      "evidence_item_id": "ev_atlas_sampling",
      "interpretive_steps": 0,
      "relevance_strength": "DIRECT"
    },
    {
      "op": "LINK_EVIDENCE",
      "note": "Distinguishes initially obtained donors from the QC-passing analyzed denominator.",
      "claim_id": "fcaf50f5-e520-8368-8686-6911ddba5235",
      "direction": "QUALIFY",
      "evidence_item_id": "ev_atlas_qc",
      "interpretive_steps": 0,
      "relevance_strength": "DIRECT"
    },
    {
      "op": "LINK_EVIDENCE",
      "note": "Limits interpretation of gene-regulation counts across cell classes and subclasses.",
      "claim_id": "fcaf50f5-e520-8368-8686-6911ddba5235",
      "direction": "QUALIFY",
      "evidence_item_id": "ev_atlas_limits",
      "interpretive_steps": 0,
      "relevance_strength": "DIRECT"
    },
    {
      "op": "LINK_EVIDENCE",
      "note": "Adds the donor age range and sex-balance context.",
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      "direction": "QUALIFY",
      "evidence_item_id": "ev_atlas_age",
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  ],
  "outcome": "QUALIFIERS_FOUND",
  "searched": "Read the full Nature Genetics article, including Abstract, Main, Genetic regulation, Methods, Sample selection and preprocessing, and pseudobulk eQTL analysis. Checked anatomical region, postmortem status, ancestry composition, donor and nucleus QC denominators, age range, cell-resolution definitions, gene-count interpretation, and per-cell-type sampling/statistical-power limits."
}

Rows created

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• EvidenceClaimLink 70e2003b-3c74-87a0-a5ff-176963aaf9b8 (accepted seq 25462)

Status history

Audits

None.

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