Contribution seq 25466

Payload

{
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    {
      "op": "CREATE_SOURCE",
      "ref": "psychad_atlas_primary_support_20260929",
      "title": "Single-nucleus atlas of cell-type specific genetic regulation in the human brain",
      "publisher": "Nature Genetics",
      "source_type": "PRIMARY_TEXT",
      "retrieved_at": "2026-09-29T05:38:00Z",
      "canonical_uri": "https://www.nature.com/articles/s41588-026-02733-5",
      "publication_date": "2026-09-23"
    },
    {
      "op": "CREATE_SOURCE_LOCATION",
      "ref": "psychad_scope_support",
      "excerpt": "In this work, we collected 5.6 million nuclei from the human dorsolateral prefrontal cortex (DLPFC) of a genetically diverse set of 1,384 donors from the full PsychAD dataset, 35.6% of whom are of non-European ancestry. A total of 1,384 donors with genotype data and snRNA-seq data passing quality control were analyzed in this study.",
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      "source_id": "psychad_atlas_primary_support_20260929",
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      "locator_type": "QUOTE"
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    {
      "op": "CREATE_SOURCE_LOCATION",
      "ref": "psychad_gene_support",
      "excerpt": "Through multi-resolution analyses spanning eight major cell classes and 27 subclasses, we identify genetic regulation for 14,258 genes.",
      "locator": {},
      "source_id": "psychad_atlas_primary_support_20260929",
      "excerpt_hash": "sha256:c36e1c85314cc6e6c4bb3c6efab5185bfbb821188e2f75de6f5bd5205c83341b",
      "locator_type": "QUOTE"
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    {
      "op": "CREATE_SOURCE_LOCATION",
      "ref": "psychad_power_support",
      "excerpt": "The number of detected eGenes increases with cell type abundance... Further stratification into 27 cell subclasses enhances cellular resolution but often reduces statistical power relative to class-level analyses because of decreased sample sizes within each subclass.",
      "locator": {},
      "source_id": "psychad_atlas_primary_support_20260929",
      "excerpt_hash": "sha256:f43b3c919685a49218de89ccbedf1ac17d4e61fe4fb7d2caec6b99d571347e23",
      "locator_type": "QUOTE"
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      "statement": "The atlas used 5.6 million DLPFC nuclei from 1,384 diverse-ancestry PsychAD donors passing genotype and snRNA-seq quality control.",
      "observation_type": "DATASET_RESULT",
      "source_location_id": "psychad_scope_support"
    },
    {
      "op": "CREATE_EVIDENCE",
      "ref": "ev_psychad_gene_support",
      "statement": "The article reports 14,258 regulated genes across eight major classes and 27 subclasses.",
      "observation_type": "DIRECT_TEXT",
      "source_location_id": "psychad_gene_support"
    },
    {
      "op": "CREATE_EVIDENCE",
      "ref": "ev_psychad_power_support",
      "statement": "eGene detection varies with cell abundance, and subclass resolution reduces power with smaller subclass sample sizes.",
      "observation_type": "DIRECT_TEXT",
      "source_location_id": "psychad_power_support"
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      "interpretive_steps": 0,
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  "outcome": "FOUND"
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Rows created

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Status history

Audits

None.

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