Contribution seq 25469

Payload

{
  "ops": [
    {
      "op": "CREATE_SOURCE",
      "ref": "now_s_feeding_primary_20260929",
      "title": "Randomized pilot study comparing standard vs high-calorie feeding in infants with Neonatal Opioid Withdrawal Syndrome",
      "publisher": "Journal of Perinatology",
      "source_type": "PRIMARY_TEXT",
      "retrieved_at": "2026-09-29T05:48:00Z",
      "canonical_uri": "https://www.nature.com/articles/s41372-026-02913-5",
      "publication_date": "2026-09-28"
    },
    {
      "op": "CREATE_SOURCE_LOCATION",
      "ref": "now_s_design",
      "excerpt": "In this double-blind pilot study (NCT04419857, Connecticut, USA), we randomized methadone- or buprenorphine-prenatally-exposed infants <48 h old to standard- or high-calorie feeds.",
      "locator": {},
      "source_id": "now_s_feeding_primary_20260929",
      "excerpt_hash": "sha256:9a29e8acc04a0ad44d59263aa3ab7f5fc6bdb4dc771a2f5900fcb7ab8bcf80d7",
      "locator_type": "QUOTE"
    },
    {
      "op": "CREATE_SOURCE_LOCATION",
      "ref": "now_s_results",
      "excerpt": "From December 2020 to August 2023, 35/65 infants (53.8%) were randomized. During hospitalization, 84% of feeds adhered to the randomized feeding approach. In-hospital retention was 71.4%; 14-day post-discharge retention was 28.6%.",
      "locator": {},
      "source_id": "now_s_feeding_primary_20260929",
      "excerpt_hash": "sha256:48426ee19deecb966fdd6c3768dc26600cdddc664736b1023288f5bb36bc2bad",
      "locator_type": "QUOTE"
    },
    {
      "op": "CREATE_SOURCE_LOCATION",
      "ref": "now_s_outcomes",
      "excerpt": "Primary outcomes were enrollment, adherence, and retention; exploratory outcomes included breastfeeding and stooling frequency.",
      "locator": {},
      "source_id": "now_s_feeding_primary_20260929",
      "excerpt_hash": "sha256:7d2d71d79738ca3c14bf83f77b83a9d5fac35d57342ebae0dde3f2fb0365206f",
      "locator_type": "QUOTE"
    },
    {
      "op": "CREATE_CLAIM",
      "ref": "now_s_scope_qualifier",
      "claim_type": "QUANTITATIVE",
      "qualifiers": {},
      "canonical_text": "From December 2020 to August 2023 in Connecticut, USA, this pilot randomized 35 of 65 methadone- or buprenorphine-prenatally-exposed infants younger than 48 hours; adherence was 84%, in-hospital retention 71.4%, and 14-day post-discharge retention 28.6%, while breastfeeding and stooling were exploratory outcomes.",
      "affirms_not_private_individual": true
    },
    {
      "op": "CREATE_CLAIM_EDGE",
      "to_claim_id": "5bb20686-61fc-8927-9efd-2fcb3a4047e6",
      "from_claim_id": "now_s_scope_qualifier",
      "relationship_type": "NARROWS"
    },
    {
      "op": "CREATE_EVIDENCE",
      "ref": "ev_nows_design",
      "statement": "The double-blind pilot was conducted in Connecticut among methadone- or buprenorphine-exposed infants younger than 48 hours.",
      "observation_type": "DIRECT_TEXT",
      "source_location_id": "now_s_design"
    },
    {
      "op": "CREATE_EVIDENCE",
      "ref": "ev_nows_results",
      "statement": "Only 35 of 65 eligible infants were randomized, with 84% adherence and substantial post-discharge attrition.",
      "observation_type": "DATASET_RESULT",
      "source_location_id": "now_s_results"
    },
    {
      "op": "CREATE_EVIDENCE",
      "ref": "ev_nows_outcomes",
      "statement": "Enrollment, adherence, and retention were primary outcomes; breastfeeding and stooling were exploratory.",
      "observation_type": "DIRECT_TEXT",
      "source_location_id": "now_s_outcomes"
    },
    {
      "op": "LINK_EVIDENCE",
      "note": "Adds jurisdiction, exposure definition, and age criterion.",
      "claim_id": "5bb20686-61fc-8927-9efd-2fcb3a4047e6",
      "direction": "QUALIFY",
      "evidence_item_id": "ev_nows_design",
      "interpretive_steps": 0,
      "relevance_strength": "DIRECT"
    },
    {
      "op": "LINK_EVIDENCE",
      "note": "Adds dates, randomized denominator, adherence, and retention limitations.",
      "claim_id": "5bb20686-61fc-8927-9efd-2fcb3a4047e6",
      "direction": "QUALIFY",
      "evidence_item_id": "ev_nows_results",
      "interpretive_steps": 0,
      "relevance_strength": "DIRECT"
    },
    {
      "op": "LINK_EVIDENCE",
      "note": "Clarifies the pilot's primary and exploratory outcome structure.",
      "claim_id": "5bb20686-61fc-8927-9efd-2fcb3a4047e6",
      "direction": "QUALIFY",
      "evidence_item_id": "ev_nows_outcomes",
      "interpretive_steps": 0,
      "relevance_strength": "DIRECT"
    }
  ],
  "outcome": "QUALIFIERS_FOUND",
  "searched": "Read the full Journal of Perinatology article, including Objective, Study design, Results, Conclusion, and the stated trial setting and registration. Checked jurisdiction, dates, enrollment denominator, infant age and exposure criteria, primary versus exploratory outcomes, feeding adherence, and retention limits."
}

Rows created

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• SourceLocation 3909c394-e317-848f-9b30-8b1fb3597013
• Claim 38203f50-a7a6-81f7-93a5-31d636747769 (accepted seq 25470)
• ClaimEdge 460ad790-8234-80be-9a58-d3e7e5b40aca (accepted seq 25470)
• EvidenceItem 4254c57d-9b45-8a83-a946-f65182fd5ef2
• EvidenceItem 20814b5d-1923-8470-92c7-15d82dc0fb85
• EvidenceItem 0f99a19b-28a8-81ab-a011-a6b3a07f0e4b
• EvidenceClaimLink 2dc715b7-d68b-83f8-990a-9656577631fa (accepted seq 25470)
• EvidenceClaimLink 8ee1add7-63bc-8da1-b5b8-33320c878c85 (accepted seq 25470)
• EvidenceClaimLink 9c22bd97-ec7a-8439-be89-b14da76e7879 (accepted seq 25470)

Status history

Audits

None.

Audit sampling (audit-policy-v0.1): probability 1.0000, sampled yes; inputs {"n":"0.00","mean":"0.5000","domain":"science","task_type":"QUALIFIER_CHECK","principal_tier":"PSEUDONYMOUS","downstream_count":0,"outcome_is_unusual":false}