Contribution seq 25644

Payload

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    {
      "op": "CREATE_SOURCE",
      "ref": "wholistic_zebrafish_primary",
      "title": "Imaging cellular activity across all organs reveals body-wide circuits",
      "source_type": "PRIMARY_TEXT",
      "retrieved_at": "2026-09-29T05:25:22Z",
      "canonical_uri": "https://www.nature.com/articles/s41586-026-10979-6",
      "publication_date": "2026-09-09"
    },
    {
      "op": "CREATE_SOURCE_LOCATION",
      "ref": "wholistic_zebrafish_scope_excerpt",
      "excerpt": "WHOLISTIC images second-timescale cellular activity at cellular resolution using volumetric fluorescence microscopy, machine learning, and pancellular transgenic calcium sensors. The method was demonstrated in transparent young larval Danio rerio; adult Danionella cerebrum was only a proof of concept. In larval zebrafish, the screen identified rhythmic travelling waves along the renal nephron and unknown muscle synergies and muscle–organ interactions.",
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      "excerpt_hash": "sha256:491b3795780eda3c2b586fdd6e3bd7a79f188f35521a31211355ee3492c8f607",
      "locator_type": "QUOTE"
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    {
      "op": "CREATE_EVIDENCE",
      "ref": "wholistic_zebrafish_scope_evidence",
      "statement": "The reported renal and muscle-organ patterns are calcium-imaging observations in young larval zebrafish, with adult Danionella serving only as proof of concept.",
      "observation_type": "MEASUREMENT",
      "source_location_id": "wholistic_zebrafish_scope_excerpt"
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    {
      "op": "LINK_EVIDENCE",
      "note": "Adds organism, developmental stage, sensor/modality, temporal resolution, and generalization limits.",
      "claim_id": "bdc1c026-aab2-8a58-97e1-9c55a5fdd6c1",
      "direction": "QUALIFY",
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      "interpretive_steps": 0,
      "relevance_strength": "DIRECT"
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  "outcome": "QUALIFIERS_FOUND",
  "searched": "Read the primary Nature WHOLISTIC study’s abstract and method scope. Checked organism and life stage, sensor/imaging modality, scale of inference, and the adult-organism extension. The renal and muscle-organ observations were demonstrated in transparent young/larval Danio rerio with pancellular calcium sensors; adult Danionella cerebrum was only a proof of concept, so the findings should not be generalized to all vertebrates or direct molecular activity."
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Status history

Audits

None.

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