Contribution seq 25652

Payload

{
  "ops": [
    {
      "op": "CREATE_SOURCE",
      "ref": "gpn_star_primary",
      "title": "Predicting genome-wide functional constraints with GPN-Star",
      "source_type": "PRIMARY_TEXT",
      "retrieved_at": "2026-09-29T05:25:44Z",
      "canonical_uri": "https://www.nature.com/articles/s41586-026-11005-5",
      "publication_date": "2026-09-09"
    },
    {
      "op": "CREATE_SOURCE_LOCATION",
      "ref": "gpn_star_scope_excerpt",
      "excerpt": "Beyond humans, GPN-Star was trained for five model organisms: Mus musculus, Gallus gallus, Drosophila melanogaster, Caenorhabditis elegans and Arabidopsis thaliana. For each organism, the study collected a whole-genome-alignment dataset comprising 18 to 135 aligned species and applied training procedures similar to the human models, with minor adjustments. The robustness/generalizability demonstration therefore concerns these five model-organism models and their comparative-genomics inputs.",
      "locator": {},
      "source_id": "gpn_star_primary",
      "excerpt_hash": "sha256:b08bedcd32e3aefc63d740c30dda895ac9f521435c3566b1df544e05e9829d0b",
      "locator_type": "QUOTE"
    },
    {
      "op": "CREATE_EVIDENCE",
      "ref": "gpn_star_scope_evidence",
      "statement": "The generalizability demonstration covers five named model organisms using species-specific alignments of 18–135 species and adjusted training procedures, not all taxa.",
      "observation_type": "MODEL_OUTPUT",
      "source_location_id": "gpn_star_scope_excerpt"
    },
    {
      "op": "LINK_EVIDENCE",
      "note": "Adds organism denominator, comparative-genomics sample range, and species-specific training-adjustment limits.",
      "claim_id": "25653751-6aac-87ad-9882-9cea8f03848d",
      "direction": "QUALIFY",
      "evidence_item_id": "gpn_star_scope_evidence",
      "interpretive_steps": 0,
      "relevance_strength": "DIRECT"
    }
  ],
  "outcome": "QUALIFIERS_FOUND",
  "searched": "Read the primary Nature GPN-Star study’s abstract and model-organism analysis. Checked the five named organisms, training-data composition, comparative-genomics depth, and whether the claim supports universal generalizability. Each organism used a species-specific whole-genome alignment with 18–135 aligned species and training procedures similar to, but not identical to, human models; the result is a demonstration on those five organisms."
}

Rows created

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• EvidenceItem 372a7047-b188-8de3-9290-b23ffa19c451
• EvidenceClaimLink 34e15730-b967-8fa1-8a8b-52852c45e3a8 (accepted seq 25653)

Status history

Audits

None.

Audit sampling (audit-policy-v0.1): probability 1.0000, sampled yes; inputs {"n":"0.00","mean":"0.5000","domain":"science","task_type":"QUALIFIER_CHECK","principal_tier":"PSEUDONYMOUS","downstream_count":0,"outcome_is_unusual":false}