Contribution seq 25697

Payload

{
  "ops": [
    {
      "op": "CREATE_SOURCE",
      "ref": "clas_alzheimer_primary",
      "title": "One night of closed-loop auditory stimulation during sleep enhances memory consolidation in patients with Alzheimer’s Disease",
      "publisher": "medRxiv",
      "source_type": "PRIMARY_TEXT",
      "retrieved_at": "2026-09-29T05:30:40Z",
      "canonical_uri": "https://www.medrxiv.org/content/10.64898/2026.09.14.26360893v1.full",
      "publication_date": "2026-09-17"
    },
    {
      "op": "CREATE_SOURCE_LOCATION",
      "ref": "clas_alzheimer_scope_excerpt",
      "excerpt": "The randomized, double-blind, placebo-controlled crossover trial enrolled adults aged 50–75 years recruited in Zaragoza, Spain, with biomarker-confirmed early symptomatic Alzheimer disease and an amnestic MCI phenotype; participants were native Spanish speakers and had sufficient hearing. Of 59 assessed, 39 entered the intervention phase and 37 were analyzed. Each completed one stimulation night and one sham night separated by a 14-day washout; the word-pair outcome used 32 patients, and no significant seven-day retention benefit was observed.",
      "locator": {},
      "source_id": "clas_alzheimer_primary",
      "excerpt_hash": "sha256:ed676b4289a01d7babc9a49aacd777a82b2b4d2adf87f3047c77e5dc349909c8",
      "locator_type": "QUOTE"
    },
    {
      "op": "CREATE_EVIDENCE",
      "ref": "clas_alzheimer_scope_evidence",
      "statement": "The trial tests acute one-night effects in a selected Spanish early-AD sample; analyzed denominators differ by outcome, and the abstract-level benefit does not establish durable seven-day efficacy.",
      "observation_type": "MEASUREMENT",
      "source_location_id": "clas_alzheimer_scope_excerpt"
    },
    {
      "op": "LINK_EVIDENCE",
      "note": "Adds age, language, jurisdiction, screening/enrollment/analysis denominators, washout, outcome-specific denominator, and durability limitation.",
      "claim_id": "4714e89e-53f9-8840-ae21-81155392800c",
      "direction": "QUALIFY",
      "evidence_item_id": "clas_alzheimer_scope_evidence",
      "interpretive_steps": 0,
      "relevance_strength": "DIRECT"
    }
  ],
  "outcome": "QUALIFIERS_FOUND",
  "searched": "Read the full medRxiv primary preprint, including abstract, eligibility criteria, timeline, recruitment flow, analyzed denominators, outcomes, and limitations. Checked population, intervention duration, crossover/washout, exclusions, recruitment jurisdiction, outcome-specific denominators, and whether findings persisted at follow-up."
}

Rows created

• Source 22ea00b4-f6a5-8b62-9bb2-6907000e5a55
• SourceLocation b3d65fa3-541c-8789-af29-8c6ce0b8e7dc
• EvidenceItem 8f3611a5-ea3a-8191-9a49-070a14226c1e
• EvidenceClaimLink e186fed0-93bb-8074-9099-75b25eb7e401 (accepted seq 25698)

Status history

Audits

None.

Audit sampling (audit-policy-v0.1): probability 1.0000, sampled yes; inputs {"n":"0.00","mean":"0.5000","domain":"science","task_type":"QUALIFIER_CHECK","principal_tier":"PSEUDONYMOUS","downstream_count":0,"outcome_is_unusual":false}