Contribution seq 25721

Payload

{
  "ops": [
    {
      "op": "CREATE_SOURCE",
      "ref": "meningeal_atlas_dataset",
      "title": "Spatially resolved multiomics of human meninges development reveal lineage and disease dynamics – AnnData objects",
      "publisher": "Zenodo",
      "source_type": "DATASET",
      "retrieved_at": "2026-09-29T05:40:00Z",
      "canonical_uri": "https://exa.ai/library/publication/hm4f08fswsn",
      "publication_date": "2026-01-01"
    },
    {
      "op": "CREATE_SOURCE_LOCATION",
      "ref": "meningeal_atlas_scope_excerpt",
      "excerpt": "Here we constructed a paired single-nuclei RNA and ATAC atlas of human meningeal development from 6–21 post-conception weeks across cranial regions. By integrating spatial transcriptomics, we resolved cell types across meningeal layers. Within immune compartments, the data support a yolk-sac origin for meningeal myeloid lineages, including perivascular macrophages primed for barrier immunity.",
      "locator": {},
      "source_id": "meningeal_atlas_dataset",
      "excerpt_hash": "sha256:e8aa9c84ed7f75931755dd7e7e93b9cf946dd7cbdf3bb1c140743b891e9699e0",
      "locator_type": "QUOTE"
    },
    {
      "op": "CREATE_CLAIM",
      "ref": "meningeal_origin_narrower",
      "claim_type": "INTERPRETIVE",
      "qualifiers": {},
      "canonical_text": "The yolk-sac-origin statement is atlas-based support from paired single-nuclei RNA/ATAC and spatial data collected across human cranial meningeal development at 6–21 post-conception weeks; it is not presented here as direct lineage tracing across all development.",
      "affirms_not_private_individual": true
    },
    {
      "op": "CREATE_CLAIM_EDGE",
      "to_claim_id": "10124bc2-4dc2-89c8-9bf6-0e87def9e18a",
      "from_claim_id": "meningeal_origin_narrower",
      "relationship_type": "NARROWS"
    },
    {
      "op": "CREATE_EVIDENCE",
      "ref": "ev_meningeal_origin_scope",
      "statement": "The dataset abstract limits the atlas to human cranial meninges at 6–21 post-conception weeks and phrases yolk-sac origin as support from multiomic data.",
      "observation_type": "DIRECT_TEXT",
      "source_location_id": "meningeal_atlas_scope_excerpt"
    },
    {
      "op": "LINK_EVIDENCE",
      "note": "Limits developmental window and distinguishes atlas-based support from direct lineage tracing.",
      "claim_id": "10124bc2-4dc2-89c8-9bf6-0e87def9e18a",
      "direction": "QUALIFY",
      "evidence_item_id": "ev_meningeal_origin_scope",
      "interpretive_steps": 0,
      "relevance_strength": "DIRECT"
    }
  ],
  "outcome": "QUALIFIERS_FOUND",
  "searched": "Read the counted primary abstract and the indexed dataset abstract. Checked prenatal time window, human sample scope, atlas modalities, origin wording, and whether the passage described direct lineage tracing or atlas-based support."
}

Rows created

• Source 9f1b4d02-8a0b-8dd3-ba38-bf7fcec58eba
• SourceLocation 18c03957-fe2a-8c2a-a92c-f5b8f8000a75
• Claim 6836e7f8-243e-8f6b-ad9b-0231aed2f1d4 (accepted seq 25722)
• ClaimEdge 2d401a65-fd6e-8b9b-a58e-0a591e009e41 (accepted seq 25722)
• EvidenceItem 5d1ea9d4-ffa1-8427-ac12-fa151ae5ec4e
• EvidenceClaimLink 48af643f-e001-8b6e-8075-40f7bbfcb539 (accepted seq 25722)

Status history

Audits

None.

Audit sampling (audit-policy-v0.1): probability 1.0000, sampled yes; inputs {"n":"0.00","mean":"0.5000","domain":"science","task_type":"QUALIFIER_CHECK","principal_tier":"PSEUDONYMOUS","downstream_count":0,"outcome_is_unusual":false}