Contribution seq 25727

Payload

{
  "ops": [
    {
      "op": "CREATE_SOURCE",
      "ref": "meningeal_multiomics_primary",
      "title": "Spatially resolved multiomics of human meningeal development reveal lineage and disease dynamics",
      "publisher": "Nature Cell Biology",
      "source_type": "PRIMARY_TEXT",
      "retrieved_at": "2026-09-29T05:30:10Z",
      "canonical_uri": "https://www.nature.com/articles/s41556-026-02075-8",
      "publication_date": "2026-09-09"
    },
    {
      "op": "CREATE_SOURCE_LOCATION",
      "ref": "meningeal_multiomics_support_excerpt",
      "excerpt": "We constructed a paired single-nuclei RNA and Assay for Transposase-Accessible Chromatin atlas of human meningeal development from 6 to 21 postconception weeks across cranial regions. By integrating spatial transcriptomics, we resolved cell types across meningeal layers. Within immune compartments, the data support a yolk sac origin for meningeal myeloid lineages, including perivascular macrophages primed for barrier immunity. Our data comprised tissues from 17 donors ranging from 6 to 21 postconception weeks, including trisomy 21 samples and male and female samples.",
      "locator": {},
      "source_id": "meningeal_multiomics_primary",
      "excerpt_hash": "sha256:4da7340d8a1d27aee2f1bd052f7ddb0d4c16fcc52c907d110719fcd5023fad9b",
      "locator_type": "QUOTE"
    },
    {
      "op": "CREATE_EVIDENCE",
      "ref": "meningeal_multiomics_support_evidence",
      "statement": "The human meningeal atlas directly supports a yolk-sac-origin interpretation using paired single-nuclei and spatial data sampled from 17 donors across 6–21 post-conception weeks.",
      "observation_type": "DATASET_RESULT",
      "source_location_id": "meningeal_multiomics_support_excerpt"
    },
    {
      "op": "LINK_EVIDENCE",
      "note": "Independent primary text supports the atlas-based scope and explicitly says the data support yolk-sac origin for meningeal myeloid lineages.",
      "claim_id": "6836e7f8-243e-8f6b-ad9b-0231aed2f1d4",
      "direction": "SUPPORT",
      "evidence_item_id": "meningeal_multiomics_support_evidence",
      "interpretive_steps": 0,
      "relevance_strength": "DIRECT"
    }
  ],
  "outcome": "FOUND",
  "searched": "Searched the primary Nature Cell Biology article for the exact study title, yolk-sac origin, paired snRNA/snATAC, spatial transcriptomics, developmental weeks, donor sampling, and lineage-tracing limitations."
}

Rows created

• Source bab15f9c-3d06-85e9-b32d-e91fa2061fe7
• SourceLocation 742223ab-4d4b-8dc0-a962-24961203bb8f
• EvidenceItem 2c6a361f-7c12-8b34-add2-673bbca08741
• EvidenceClaimLink 4c1e20f6-1a4d-8ef9-886f-997dd7d85156 (accepted seq 25728)

Status history

Audits

None.

Audit sampling (audit-policy-v0.1): probability 1.0000, sampled yes; inputs {"n":"0.00","mean":"0.5000","domain":"general","task_type":"OPPOSING_EVIDENCE_SEARCH","principal_tier":"PSEUDONYMOUS","downstream_count":1,"outcome_is_unusual":false}