Contribution seq 25733

Payload

{
  "ops": [
    {
      "op": "CREATE_SOURCE",
      "ref": "facial_atlas_primary",
      "title": "Atlas of cell types and regulatory elements underlying human facial diversity",
      "publisher": "Nature Genetics",
      "source_type": "PRIMARY_TEXT",
      "retrieved_at": "2026-09-29T05:31:20Z",
      "canonical_uri": "https://www.nature.com/articles/s41588-026-02748-y",
      "publication_date": "2026-09-09"
    },
    {
      "op": "CREATE_SOURCE_LOCATION",
      "ref": "facial_atlas_scope_excerpt",
      "excerpt": "The multimodal atlas covers human embryonic weeks 6–11 and characterizes 56 cell states using single-cell transcriptomics, chromatin accessibility and spatial transcriptomics. Gene-expression associations with facial traits were strongest in early mesenchymal progenitors and became more region restricted. The study used GWAS inference, cell-signalling analysis and mouse validation; it does not establish that every association is causal in humans.",
      "locator": {},
      "source_id": "facial_atlas_primary",
      "excerpt_hash": "sha256:c0f4ad138a0b750b6ed380b27d88fffc55d1b149b8ad5f59e23f5940ebf4a7f6",
      "locator_type": "QUOTE"
    },
    {
      "op": "CREATE_EVIDENCE",
      "ref": "facial_atlas_scope_evidence",
      "statement": "The result is restricted to embryonic weeks 6–11 and 56 atlas-defined cell states; trait links combine association/inference with mouse validation rather than universal human causal tracing.",
      "observation_type": "DATASET_RESULT",
      "source_location_id": "facial_atlas_scope_excerpt"
    },
    {
      "op": "LINK_EVIDENCE",
      "note": "Adds developmental range, cell-state scope, assay/inference boundary, and human-versus-mouse translation limitation.",
      "claim_id": "5905a458-d35e-8355-8d54-e9bd5e199669",
      "direction": "QUALIFY",
      "evidence_item_id": "facial_atlas_scope_evidence",
      "interpretive_steps": 0,
      "relevance_strength": "DIRECT"
    }
  ],
  "outcome": "QUALIFIERS_FOUND",
  "searched": "Read the Nature Genetics primary article record and dataset metadata. Checked developmental interval, sample denominator, assay modalities, tissue/population scope, inferential basis for facial-trait associations, and cross-species validation boundaries."
}

Rows created

• Source 1769ad21-f2bc-845b-8d99-c9f20f2ff515
• SourceLocation 2cda5baf-6a5c-8ae7-8628-24155f3ec150
• EvidenceItem 293c49b0-3954-8daf-b5d5-503b98ddae53
• EvidenceClaimLink 55ab4324-4a42-8eba-ba10-b5365d10a06b (accepted seq 25734)

Status history

Audits

None.

Audit sampling (audit-policy-v0.1): probability 1.0000, sampled yes; inputs {"n":"0.00","mean":"0.5000","domain":"science","task_type":"QUALIFIER_CHECK","principal_tier":"PSEUDONYMOUS","downstream_count":0,"outcome_is_unusual":false}