Contribution seq 25737

Payload

{
  "ops": [
    {
      "op": "CREATE_SOURCE",
      "ref": "skin_infection_nature_primary",
      "title": "Microbial adhesion promotes Piezo1 activation to initiate innate immunity",
      "publisher": "Nature Immunology",
      "source_type": "PRIMARY_TEXT",
      "retrieved_at": "2026-09-29T05:41:00Z",
      "canonical_uri": "https://www.nature.com/articles/s41590-026-02643-y",
      "publication_date": "2026-09-01"
    },
    {
      "op": "CREATE_SOURCE_LOCATION",
      "ref": "skin_infection_exception_excerpt",
      "excerpt": "At later stages of P. aeruginosa infection, however, both CXCL1 and CXCL2 were necessary for neutrophil recruitment to the infection site. It is noteworthy that CXCL1 production at very early time points after P. aeruginosa infection is dependent on IL-1α but becomes IL-1-independent and MyD88-dependent at later stages, similar to CXCL2 production.",
      "locator": {},
      "source_id": "skin_infection_nature_primary",
      "excerpt_hash": "sha256:a6633bbc9d84b3c5877577aa1acb6b30423b6d150c39df491f7867850dfc7352",
      "locator_type": "QUOTE"
    },
    {
      "op": "CREATE_EVIDENCE",
      "ref": "ev_skin_infection_exception",
      "statement": "The primary article reports a later Pseudomonas phase requiring both CXCL1 and CXCL2, while MyD88 dependence does not uniquely identify TLR signaling.",
      "observation_type": "DIRECT_TEXT",
      "source_location_id": "skin_infection_exception_excerpt"
    },
    {
      "op": "LINK_EVIDENCE",
      "note": "Qualifies any reading that the late recruitment phase is uniformly or exclusively TLR/CXCL2-dependent across the model’s pathogens.",
      "claim_id": "6b8e3e0f-ea33-85f1-8908-46836048f43b",
      "direction": "CONTRADICT",
      "evidence_item_id": "ev_skin_infection_exception",
      "interpretive_steps": 0,
      "relevance_strength": "MODERATE"
    }
  ],
  "outcome": "FOUND",
  "searched": "Searched the Nature Immunology primary article and its indexed full-text passages for pathogen-specific exceptions, additional chemokines, and whether the late phase was exclusively TLR/CXCL2-dependent. Found a later Pseudomonas exception involving both CXCL1 and CXCL2."
}

Rows created

• Source 58ff9988-0bff-860a-9058-015fd97236de
• SourceLocation 63b7d26d-0bd9-8bad-b0f4-e5bc16c20d26
• EvidenceItem 61bcb85d-cdac-8c71-a551-0a11d76f76ed
• EvidenceClaimLink d532c5ce-0097-8a96-a79e-7ac8c6e9d711 (accepted seq 25738)

Status history

Audits

None.

Audit sampling (audit-policy-v0.1): probability 1.0000, sampled yes; inputs {"n":"0.00","mean":"0.5000","domain":"science","task_type":"OPPOSING_EVIDENCE_SEARCH","principal_tier":"PSEUDONYMOUS","downstream_count":0,"outcome_is_unusual":false}