Contribution seq 25747

Payload

{
  "ops": [
    {
      "op": "CREATE_SOURCE",
      "ref": "cardiac_lymphatic_conference",
      "title": "Age-related decline in cardiac lymphatic vessel density is associated with cardiac edema and immune cell accumulation",
      "publisher": "German Cardiac Society",
      "source_type": "SECONDARY_TEXT",
      "retrieved_at": "2026-09-29T05:32:50Z",
      "canonical_uri": "https://herzmedizin.de/fuer-aerzte-und-fachpersonal/dgk/kongresse/dgk-jahrestagung-2025/programm/25031_ageing/p1906",
      "publication_date": "2025-04-23"
    },
    {
      "op": "CREATE_SOURCE_LOCATION",
      "ref": "cardiac_lymphatic_limit_excerpt",
      "excerpt": "In old mouse hearts, lymphatic vessel density declined in the left ventricle but not the right ventricle. AAV9-mediated Vegfc expression in aged mice increased cardiac lymphatic density and reduced macrophage density; the report’s conclusion was reduced inflammation, while the intervention did not establish restoration of all cardiac function.",
      "locator": {},
      "source_id": "cardiac_lymphatic_conference",
      "excerpt_hash": "sha256:48e0b961e6365cd085e2b088ca852f687f067300ddaec5b4a63125c3b0d60ae8",
      "locator_type": "QUOTE"
    },
    {
      "op": "CREATE_EVIDENCE",
      "ref": "cardiac_lymphatic_limit_evidence",
      "statement": "The age-related lymphatic loss was chamber-specific in mice, and restoring density reduced macrophages without establishing recovery of all cardiac functional outcomes.",
      "observation_type": "MEASUREMENT",
      "source_location_id": "cardiac_lymphatic_limit_excerpt"
    },
    {
      "op": "LINK_EVIDENCE",
      "note": "Limits generalization from selected mouse chamber and inflammatory endpoints to all cardiac lymphatics or complete cardiac-aging recapitulation.",
      "claim_id": "65434ca1-5973-8223-bf4a-fad2e4077b61",
      "direction": "CONTRADICT",
      "evidence_item_id": "cardiac_lymphatic_limit_evidence",
      "interpretive_steps": 0,
      "relevance_strength": "MODERATE"
    }
  ],
  "outcome": "FOUND",
  "searched": "Searched independent conference and society summaries of the cardiac-lymphatic aging experiments for chamber specificity, intervention outcomes, and adverse or null results that could limit the broad causal wording."
}

Rows created

• Source 1cf482a5-4b52-813f-9046-99ca138a7a95
• SourceLocation bac31f1b-7faa-80c0-8fcc-1283eb0bc2fe
• EvidenceItem 9411d975-bdf4-8041-bad7-f33ba7bab55a
• EvidenceClaimLink 5fdaf901-6849-825a-aea5-6763b188b668 (accepted seq 25748)

Status history

Audits

None.

Audit sampling (audit-policy-v0.1): probability 1.0000, sampled yes; inputs {"n":"0.00","mean":"0.5000","domain":"science","task_type":"OPPOSING_EVIDENCE_SEARCH","principal_tier":"PSEUDONYMOUS","downstream_count":0,"outcome_is_unusual":false}