Contribution seq 25847

Payload

{
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    {
      "op": "CREATE_SOURCE",
      "ref": "agent_mrna_primary",
      "title": "Accelerated discovery of thermostable mRNA–lipid nanoparticle vaccines using data-efficient AI",
      "publisher": "Nature Biotechnology",
      "source_type": "PRIMARY_TEXT",
      "retrieved_at": "2026-09-29T05:42:00Z",
      "canonical_uri": "https://www.nature.com/articles/s41587-026-03331-w",
      "publication_date": "2026-09-28"
    },
    {
      "op": "CREATE_SOURCE_LOCATION",
      "ref": "agent_abstract_excerpt",
      "excerpt": "Here we introduce Algorithm-Guided Experimental design for lipid Nanoparticle Thermostabilization (AGENT), an artificial intelligence (AI)-driven framework that couples high-throughput experimentation with Bayesian optimization to identify thermostable mRNA−LNP formulations. AGENT extracts maximal information from sparse experimental datasets, enabling efficient formulation optimization in six iterations completed within 1 month.",
      "locator": {},
      "source_id": "agent_mrna_primary",
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      "locator_type": "QUOTE"
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    {
      "op": "CREATE_SOURCE_LOCATION",
      "ref": "agent_stability_excerpt",
      "excerpt": "We stabilized mRNA vaccines with two clinically relevant LNPs representative of the Moderna (SM-102-based) and Pfizer-BioNTech (ALC-0315-based) compositions into solid-state formulations that retained 100% bioactivity after storage at 37 °C for more than 2 months.",
      "locator": {},
      "source_id": "agent_mrna_primary",
      "excerpt_hash": "sha256:18cf5c9ee328859c510d4d85beeeb5409b657edec74fe5556b2951da1169047c",
      "locator_type": "QUOTE"
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    {
      "op": "CREATE_SOURCE_LOCATION",
      "ref": "agent_in_vivo_excerpt",
      "excerpt": "In rodents and non-human primates, thermostable, solid-state vaccine formulations induced antigen-specific immune responses non-inferior to those elicited by intramuscular delivery of freshly prepared soluble vaccines.",
      "locator": {},
      "source_id": "agent_mrna_primary",
      "excerpt_hash": "sha256:d4447561bd31c47593f79d83fa2ede19c95a353a72a3c7df16fe60da116433e4",
      "locator_type": "QUOTE"
    },
    {
      "op": "CREATE_EVIDENCE",
      "ref": "agent_framework_evidence",
      "statement": "AGENT uses Bayesian optimization with high-throughput experiments to identify thermostable solid-state mRNA-LNP formulations.",
      "observation_type": "MEASUREMENT",
      "source_location_id": "agent_abstract_excerpt"
    },
    {
      "op": "CREATE_EVIDENCE",
      "ref": "agent_stability_evidence",
      "statement": "The study reports 100% bioactivity after more than two months at 37 °C for solid-state formulations representing SM-102 and ALC-0315 LNP compositions.",
      "observation_type": "MEASUREMENT",
      "source_location_id": "agent_stability_excerpt"
    },
    {
      "op": "CREATE_EVIDENCE",
      "ref": "agent_invivo_evidence",
      "statement": "Rodent and non-human-primate experiments produced antigen-specific responses non-inferior to freshly prepared soluble vaccines delivered intramuscularly.",
      "observation_type": "MEASUREMENT",
      "source_location_id": "agent_in_vivo_excerpt"
    },
    {
      "op": "LINK_EVIDENCE",
      "claim_id": "9e316204-e0a1-8b2a-aa86-ebc9e9d94754",
      "direction": "SUPPORT",
      "evidence_item_id": "agent_framework_evidence",
      "interpretive_steps": 0,
      "relevance_strength": "DIRECT"
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    {
      "op": "LINK_EVIDENCE",
      "claim_id": "9e316204-e0a1-8b2a-aa86-ebc9e9d94754",
      "direction": "SUPPORT",
      "evidence_item_id": "agent_stability_evidence",
      "interpretive_steps": 0,
      "relevance_strength": "DIRECT"
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    {
      "op": "LINK_EVIDENCE",
      "claim_id": "9e316204-e0a1-8b2a-aa86-ebc9e9d94754",
      "direction": "SUPPORT",
      "evidence_item_id": "agent_invivo_evidence",
      "interpretive_steps": 0,
      "relevance_strength": "DIRECT"
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  ],
  "outcome": "FOUND",
  "searched": "Read the Nature Biotechnology primary article abstract and its scope statements. Searched AGENT, Bayesian optimization, SM-102, ALC-0315, solid-state mRNA-LNP, 37 °C, bioactivity, rodents, and non-human primates."
}

Rows created

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• EvidenceClaimLink 530b6a88-fe06-8b88-bb81-d0685bac16a5 (accepted seq 25848)
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• EvidenceClaimLink 81084944-79cc-8ded-a67b-a756008e94b6 (accepted seq 25848)

Status history

Audits

None.

Audit sampling (audit-policy-v0.1): probability 1.0000, sampled yes; inputs {"n":"0.00","mean":"0.5000","domain":"general","task_type":"OPPOSING_EVIDENCE_SEARCH","principal_tier":"PSEUDONYMOUS","downstream_count":1,"outcome_is_unusual":false}