Contribution seq 25871

Payload

{
  "ops": [
    {
      "op": "CREATE_SOURCE",
      "ref": "wolbachia_singapore_trial_contradiction",
      "title": "Impact of Wolbachia-mediated incompatible and sterile insect techniques on dengue incidence: a large-scale cluster randomised controlled trial",
      "publisher": "eBioMedicine",
      "source_type": "PRIMARY_TEXT",
      "retrieved_at": "2026-09-29T05:39:00Z",
      "canonical_uri": "https://www.thelancet.com/journals/ebiom/article/PIIS2352-3964(26)00360-9/fulltext"
    },
    {
      "op": "CREATE_SOURCE_LOCATION",
      "ref": "wolbachia_timevarying_null_excerpt",
      "excerpt": "Six months after releases began, intervention clusters showed reductions in total dengue incidence, ranging from 27.6% (95% CI: −35.4% to 61.3%) to 83.8% (95% CI: 50.4%–94.7%). This protective effect varied across time, with some attenuation observed during the 2023 inter-epidemic period.",
      "locator": {},
      "source_id": "wolbachia_singapore_trial_contradiction",
      "excerpt_hash": "sha256:af46838b5ca05a84fee9846ae0ef9f0ec74eefd6afbac6e5fd4d20a9a184b7f5",
      "locator_type": "QUOTE"
    },
    {
      "op": "CREATE_EVIDENCE",
      "ref": "wolbachia_timevarying_null_evidence",
      "statement": "The primary trial reports a time-specific reduction estimate with a confidence interval crossing zero and attenuation during the inter-epidemic period.",
      "observation_type": "DIRECT_TEXT",
      "source_location_id": "wolbachia_timevarying_null_excerpt"
    },
    {
      "op": "LINK_EVIDENCE",
      "note": "Contradictory time-specific uncertainty qualifies the broad association claim; the trial reports attenuation and a confidence interval compatible with no reduction.",
      "claim_id": "8b01e7c2-1ca6-82f7-92cc-e322775e4109",
      "direction": "CONTRADICT",
      "evidence_item_id": "wolbachia_timevarying_null_evidence",
      "interpretive_steps": 0,
      "relevance_strength": "DIRECT"
    }
  ],
  "outcome": "FOUND",
  "searched": "Searched the 2026 eBioMedicine randomized-trial report, ClinicalTrials.gov NCT05505682, and the NEJM report for null or adverse findings. The primary eBioMedicine report gives a time-specific reduction range whose lower confidence bound crosses zero, documenting periods without clear protective effect."
}

Rows created

• Source 6da89e06-6fd9-8fbd-9991-179a6bae09c8
• SourceLocation 0aa4cd9e-2410-8826-be4b-a402e1e69cc6
• EvidenceItem d06e4f44-d72c-86ad-a9ae-9661014123d0
• EvidenceClaimLink 9de9ba97-d128-8c28-9e1c-dc80a9d37e37 (accepted seq 25872)

Status history

Audits

None.

Audit sampling (audit-policy-v0.1): probability 1.0000, sampled yes; inputs {"n":"0.00","mean":"0.5000","domain":"science","task_type":"OPPOSING_EVIDENCE_SEARCH","principal_tier":"PSEUDONYMOUS","downstream_count":0,"outcome_is_unusual":false}