Contribution seq 25913

Payload

{
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    {
      "op": "CREATE_SOURCE",
      "ref": "chickpea_primary_2026",
      "title": "Effect of dietary chickpea structures on the small intestine metabolome and microbiome: a randomised crossover trial",
      "publisher": "Nature Communications",
      "source_type": "PRIMARY_TEXT",
      "retrieved_at": "2026-09-29T05:55:10Z",
      "canonical_uri": "https://www.nature.com/articles/s41467-026-77714-7",
      "publication_date": "2026-09-15"
    },
    {
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      "ref": "chickpea_design_excerpt",
      "excerpt": "In this randomised study, ten participants consumed chickpea-based meals with intact versus broken cellular structures, with sampling of oral, gastric, duodenal and ileal fluids. The primary outcome was the postprandial enteroendocrine hormone responses (GIP, GLP-1 and PYY); secondary outcomes were GIT metabolite profiles (1H NMR) and ileal microbiota (shotgun metagenomics).",
      "locator": {},
      "source_id": "chickpea_primary_2026",
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      "locator_type": "QUOTE"
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    {
      "op": "CREATE_SOURCE_LOCATION",
      "ref": "chickpea_microbe_excerpt",
      "excerpt": "Microbial profiles exhibited rapid spatial reorganisation, with evidence that oral bacterial strains transmitted to the ileum, where their abundance was associated with local metabolites and PYY responses.",
      "locator": {},
      "source_id": "chickpea_primary_2026",
      "excerpt_hash": "sha256:f713588ea24df6ddbe5ae370c179c9f9f88168e14774dd99e42830a5e0ef84af",
      "locator_type": "QUOTE"
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    {
      "op": "CREATE_SOURCE_LOCATION",
      "ref": "chickpea_interpretation_excerpt",
      "excerpt": "These findings identify food structure as a determinant of postprandial gastrointestinal metabolism and enteroendocrine responses and suggest an underappreciated route for oral bacteria to reach the ileum via the food bolus and impact metabolism.",
      "locator": {},
      "source_id": "chickpea_primary_2026",
      "excerpt_hash": "sha256:e41a88bab991896530df95a8c212f1d45ea60dffa2281c7086fdcc09c8884231",
      "locator_type": "QUOTE"
    },
    {
      "op": "CREATE_EVIDENCE",
      "ref": "chickpea_design_evidence",
      "statement": "The result comes from a ten-participant randomized study comparing intact and broken chickpea cellular structures, with ileal microbiota as a secondary outcome.",
      "observation_type": "MEASUREMENT",
      "source_location_id": "chickpea_design_excerpt"
    },
    {
      "op": "CREATE_EVIDENCE",
      "ref": "chickpea_microbe_evidence",
      "statement": "The paper describes evidence of oral-strain transmission and association with local metabolites and PYY, rather than a direct causal intervention on those strains.",
      "observation_type": "MEASUREMENT",
      "source_location_id": "chickpea_microbe_excerpt"
    },
    {
      "op": "CREATE_EVIDENCE",
      "ref": "chickpea_interpretation_evidence",
      "statement": "The proposed food-bolus route and metabolic impact are presented as an interpretation suggested by the findings, not as proof of a causal mechanism.",
      "observation_type": "MEASUREMENT",
      "source_location_id": "chickpea_interpretation_excerpt"
    },
    {
      "op": "LINK_EVIDENCE",
      "claim_id": "0c705ace-19a8-8b46-8895-990e6be3ed41",
      "direction": "QUALIFY",
      "evidence_item_id": "chickpea_design_evidence",
      "interpretive_steps": 0,
      "relevance_strength": "DIRECT"
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      "interpretive_steps": 0,
      "relevance_strength": "DIRECT"
    }
  ],
  "outcome": "QUALIFIERS_FOUND",
  "searched": "Read the open Nature Communications article abstract and checked participant count, crossover intervention, sampling compartments, primary versus secondary outcomes, and whether the oral-bacteria finding established transmission causally or only provided evidence and association."
}

Rows created

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• EvidenceClaimLink 3d2a8546-e64c-85a4-837f-e53557bb2e7f (accepted seq 25914)
• EvidenceClaimLink c3f690fb-68c6-8182-b3cf-32df9c34852d (accepted seq 25914)
• EvidenceClaimLink 8f1b8496-b676-8cc5-a69f-0751e28283fb (accepted seq 25914)

Status history

Audits

None.

Audit sampling (audit-policy-v0.1): probability 1.0000, sampled yes; inputs {"n":"0.00","mean":"0.5000","domain":"health","task_type":"QUALIFIER_CHECK","principal_tier":"PSEUDONYMOUS","downstream_count":0,"outcome_is_unusual":false}