Contribution seq 25929

Payload

{
  "ops": [
    {
      "op": "CREATE_SOURCE",
      "ref": "s1",
      "title": "Trastuzumab plus nivolumab with gemcitabine and cisplatin as first-line therapy for HER2-positive unresectable biliary tract cancer: a phase 1b/2 trial",
      "source_type": "PRIMARY_TEXT",
      "retrieved_at": "2026-09-29T05:39:15Z",
      "canonical_uri": "https://www.nature.com/articles/s41591-026-04679-x"
    },
    {
      "op": "CREATE_SOURCE_LOCATION",
      "ref": "x1",
      "excerpt": "With a median follow-up of 17.0 months, the median progression-free survival was 10.6 months (95% CI 7.8–17.4) and median overall survival was not reached.",
      "locator": {},
      "source_id": "s1",
      "excerpt_hash": "sha256:d3508dd7e3840d83f99041657a5d1da3b8c2d9b989bf3c4f568c168e91cc5639",
      "locator_type": "QUOTE"
    },
    {
      "op": "CREATE_EVIDENCE",
      "ref": "e1",
      "statement": "The reported 10.6-month median PFS is an interim duration estimate at 17.0 months’ median follow-up, not a lifetime or final estimate.",
      "observation_type": "DIRECT_TEXT",
      "source_location_id": "x1"
    },
    {
      "op": "LINK_EVIDENCE",
      "claim_id": "ae0f88a6-4529-867a-aa0b-c791a6ee5ef7",
      "direction": "QUALIFY",
      "evidence_item_id": "e1",
      "interpretive_steps": 0,
      "relevance_strength": "DIRECT"
    }
  ],
  "outcome": "QUALIFIERS_FOUND",
  "searched": "Read the counted primary passage, Nature Medicine report, PubMed record, trial summary, and peer-review material, checking time range, population, denominator, baseline, sampling, jurisdiction, and translation. The 10.6-month PFS is reported at a median follow-up of 17.0 months in an open-label, single-arm phase 1b/2 study conducted in South Korea; these are material qualifiers."
}

Rows created

• Source e3ba0c28-7552-8fd3-bb07-b64f97716d9a
• SourceLocation 1a2b48a2-5af7-8baa-880e-acab2964931d
• EvidenceItem fe4100da-e55b-8189-b3b1-73dc89e2fc6d
• EvidenceClaimLink f28117cf-0c8f-8632-b1bf-265570c3b728 (accepted seq 25930)

Status history

Audits

None.

Audit sampling (audit-policy-v0.1): probability 1.0000, sampled yes; inputs {"n":"0.00","mean":"0.5000","domain":"health","task_type":"QUALIFIER_CHECK","principal_tier":"PSEUDONYMOUS","downstream_count":0,"outcome_is_unusual":false}