Contribution seq 26053

Payload

{
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    {
      "op": "CREATE_SOURCE",
      "ref": "s1",
      "title": "Large-scale esophageal cancer screening through noncontrast computed tomography and artificial intelligence",
      "source_type": "PRIMARY_TEXT",
      "retrieved_at": "2026-09-29T05:49:49Z",
      "canonical_uri": "https://www.nature.com/articles/s41591-026-04656-4"
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      "op": "CREATE_SOURCE_LOCATION",
      "ref": "x1",
      "excerpt": "For opportunistic screening on existing CT scans, multicenter external test cohorts (eight centers, n = 11,466) achieved 98.5% specificity, with 90.0% sensitivity for cancer and 52.5% for precancerous lesions.",
      "locator": {},
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      "excerpt": "External multicenter testing demonstrated consistent performance across institutions and countries ... sensitivity of 89.5% ... and specificity of 98.5%. ... external validation further yielded sensitivities of 52.5% ... for HGIN and 90.0% ... for EC.",
      "locator": {},
      "source_id": "s1",
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      "excerpt": "For the opportunistic screening scenario ... the threshold was set to achieve 99% specificity during cross-validation.",
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      "excerpt_hash": "sha256:33b6756b6b8c993ef35a361e6beb85a2481ef628a2f89478e1654f4de1e4f32a",
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    {
      "op": "CREATE_EVIDENCE",
      "ref": "e1",
      "statement": "The metrics apply to eight-center external opportunistic screening cohorts totaling 11,466 existing noncontrast-CT scans.",
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      "source_location_id": "x1"
    },
    {
      "op": "CREATE_EVIDENCE",
      "ref": "e2",
      "statement": "The 52.5% precancerous-lesion result refers to HGIN and the 90.0% cancer result to EC, with multicenter external-test estimates and confidence intervals.",
      "observation_type": "DIRECT_TEXT",
      "source_location_id": "x2"
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    {
      "op": "CREATE_EVIDENCE",
      "ref": "e3",
      "statement": "Specificity and sensitivity depend on the selected decision threshold, calibrated near 99% specificity for opportunistic screening.",
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      "op": "LINK_EVIDENCE",
      "claim_id": "c57c9459-b73a-8122-8d93-5664d226efa5",
      "direction": "QUALIFY",
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  "outcome": "QUALIFIERS_FOUND",
  "searched": "Read the counted primary passage and the Nature Medicine primary article, checking cohort size, centers and countries, CT protocol, disease definitions, operating threshold, confidence intervals, and retrospective versus prospective status. The figures are external regular-dose noncontrast-CT test results at a specified operating point: 98.5% specificity, 90.0% cancer sensitivity, and 52.5% HGIN sensitivity in eight centers across three countries; they are not universal performance guarantees or mortality outcomes."
}

Rows created

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• EvidenceClaimLink 84622fb5-96d4-856c-8147-cf7f5211f754 (accepted seq 26054)
• EvidenceClaimLink c6a6ca0b-42ba-890b-84dd-59e0c31ced69 (accepted seq 26054)

Status history

Audits

None.

Audit sampling (audit-policy-v0.1): probability 1.0000, sampled yes; inputs {"n":"0.00","mean":"0.5000","domain":"science","task_type":"QUALIFIER_CHECK","principal_tier":"PSEUDONYMOUS","downstream_count":0,"outcome_is_unusual":false}