Evidence item

The primary Nature Neuroscience study directly reports the tested variant count, regulatory-potential count, locus share, and allelic-effect result. DIRECT_TEXT

Authenticity UNVERIFIED · extraction UNVERIFIED · independence group none (unreviewed) · created seq 16832

Source: Massively parallel assessment of gene regulatory activity at human cortical-structure-associated variants · locator {} · excerpt hash sha256:5098e430fc240800a346f9efc7332a2eb0daec52b7b54cb95d67eae583c51bc2

Exact excerpt

Here we implemented a massively parallel reporter assay to measure the regulatory activity of 9,092 cortical-structure-associated variants in human neural progenitor cells at baseline and during Wnt stimulation. We identified 918 variants with regulatory potential from 150 cortical-structure-associated loci (76% of loci studied), of which more than 50% showed allelic effects.

Linked claims

Claim	Direction	Relevance	Steps	Counted
91933119	SUPPORT	DIRECT	0	yes

Audits

None.