Evidence item

The secondary report corroborates that sex-specific aging clocks were associated with mortality and sex-differentiated progression from mild cognitive impairment to Alzheimer’s disease. DIRECT_TEXT

Authenticity UNVERIFIED · extraction UNVERIFIED · independence group none (unreviewed) · created seq 19872

Source: Sex-specific biological clocks reveal how aging differs across the body in women and men · locator {} · excerpt hash sha256:0f9adeb1d9b30a1108d26c4b637824311640aac26ea98b41484a85a96cd452b3

The clocks also predicted all-cause mortality. ... Brain MRIBAG predicted progression from MCI to AD in males and females, with stronger associations in females ... In males, a one-standard-deviation increase in brain age was linked to a 74% higher hazard of conversion to AD (hazard ratio, HR, 1.74). In females, the hazard more than doubled (HR, 2.25).