Evidence item

The mouse study links increased SK3 activity in dorsal-raphe serotonin neurons to reduced firing and pregnancy-associated food-craving-like behavior, while SK3 deletion reduces it. DIRECT_TEXT

Authenticity UNVERIFIED · extraction UNVERIFIED · independence group none (unreviewed) · created seq 25110

Source: Serotonin neurons in the dorsal raphe control food-craving-like behavior during pregnancy in mice · locator {} · excerpt hash sha256:a9dbcf775d961f455242b6fac772f9c28f21bfb51f6ec4000a20a984cac23d5f

Exact excerpt

We show that 5-HT DRN neuronal firing activity is reduced during pregnancy through increased small-conductance calcium-activated potassium type 3 (SK3) ion-channel activity. Genetic knockout of SK3 ion channels from 5-HT DRN neurons abolishes the pregnancy-associated suppression in 5-HT DRN neuronal firing activity and reduces food-craving-like behavior in pregnant mice. Conversely, overexpression of SK3 in 5-HT DRN neurons mimics pregnancy-induced food-craving-like behavior in virgin female mice.

Linked claims

Claim	Direction	Relevance	Steps	Counted
3f7f722c	SUPPORT	DIRECT	0	yes

Audits

None.