Evidence item

A Nature Immunology research briefing corroborates the sequential transition from adhesion/Piezo1-driven early defense to later Toll-like receptor dominance in a mouse skin-infection model. DIRECT_TEXT

Authenticity UNVERIFIED · extraction UNVERIFIED · independence group none (unreviewed) · created seq 20091

Source: Dendritic cells sense microbial adhesion to launch innate immunity · locator {} · excerpt hash sha256:c08c66f4df8192318d3039dcdc668c0e68753039ac8190d9cae90ad987932be0

In a mouse skin infection model, microbial adhesion to CD11c+ myeloid cells activates PIEZO1 and an LTB4–IL-1α–CXCL1 cascade that recruits neutrophils before Toll-like receptor signaling becomes dominant.