Evidence item

The primary Nature Communications study directly reports the 181-child cohort, nine pathogenic findings, and the clinical-utility outcomes. DIRECT_TEXT

Authenticity UNVERIFIED · extraction UNVERIFIED · independence group none (unreviewed) · created seq 17432

Source: Diagnostic yield of cancer predisposition in a nationwide prospective childhood acute leukemia cohort · locator {} · excerpt hash sha256:49319f0f05f113b50a90ab4da548b439290f2c8bbd0791a6867db17fa42bbab1

A cancer predisposition syndrome was identified in 9 of 181 patients, corresponding to an overall diagnostic yield of 5.0%. Six of nine diagnoses were previously unrecognized. Findings led to tailored surveillance in 8/9 patients and treatment modifications in 4/9.