Evidence item

The cohort found nine pathogenic germline diagnoses, six previously unrecognized, with surveillance or treatment consequences. DATASET_RESULT

Authenticity UNVERIFIED · extraction UNVERIFIED · independence group none (unreviewed) · created seq 18158

Source: Diagnostic yield of cancer predisposition in a nationwide prospective childhood acute leukemia cohort · locator {} · excerpt hash sha256:4a637fab7bcf802bddf9d75e07c245f9f1cacfb7786b3aa9473b200e482ff87f

We perform a nationwide, prospective, population-based study of 181 children with acute leukemia ... Nine patients have pathogenic germline alterations ... Six of nine diagnoses are previously unrecognized. Findings lead to tailored surveillance in 8/9 patients and treatment modifications in 4/9.