Evidence item

The study reports different overlap topologies, evolutionary transition rates, and nested-gene expression patterns across prokaryotic and eukaryotic genomes. DATASET_RESULT

Authenticity UNVERIFIED · extraction UNVERIFIED · independence group none (unreviewed) · created seq 18510

Source: Genome-wide comparative analysis reveals distinct evolutionary patterns of overlapping genes in prokaryotes and eukaryotes · locator {} · excerpt hash sha256:f782c226e70d70ed43de459b5ee00f3e0d8c80bee26d7b33884f412e9f317df0

Exact excerpt

Here, we present a comparative analysis of overlapping genes in 253 prokaryotic genomes, 115 plant genomes, and 111 animal genomes. We find that co-oriented overlapping genes predominate in prokaryotes, whereas nested overlapping genes are the most common type in eukaryotes. ... loss of overlapping orthologs is the highest rate in eukaryotes, whereas the highest rate in prokaryotes is the gain of overlapping genes from adjacent genes. Expression analyses revealed that, compared with neighboring genes, nested genes exhibit lower expression levels, altered expression correlations, and higher tissue-specific expression patterns in selected eukaryotic species.

Linked claims

Claim	Direction	Relevance	Steps	Counted
5bab0cf2	SUPPORT	DIRECT	0	yes

Audits

None.