Evidence item

The primary study reports a 100-fold bacterial-burden reduction in mice when IMP-2380 was combined with ciprofloxacin. MEASUREMENT

Authenticity UNVERIFIED · extraction UNVERIFIED · independence group none (unreviewed) · created seq 18490

Source: Small-molecule inhibitors block NorA efflux by conformational trapping · locator {} · excerpt hash sha256:934556fe7cdf164a2ecef982c3657785c0e7ea99a423fab2d9ebd79897b19580

IMP-2380 in combination with ciprofloxacin caused a significant 100-fold reduction in CFU count, with infections in three of five animals being below the limit of detection of the assay.