Evidence item

A cardiac-medicine conference summary reports threefold lymphatic-density restoration and reduced macrophage density after Vegfc expression in aged mice. DIRECT_TEXT

Authenticity UNVERIFIED · extraction UNVERIFIED · independence group none (unreviewed) · created seq 21004

Source: Age-Associated Loss of Lymphatic Vessels Promotes Cardiac Inflammation · locator {} · excerpt hash sha256:024d8e048cd0d5b42b504ece1693e1a79f7922797c0967a73c92875739a373e8

Indeed, AAV9-mediated Vegfc gene expression in aged mice increased cardiac lymphatic density by 3-fold and reduced CD68+ macrophage density... In conclusion, our study demonstrates an age-related reduction in LV lymphatic density, with cardiac edema and inflammation which can be restored therapeutically using Vegfc.