Evidence item

The study reports SA-dependent NPR1–MED15A interaction and NIMIN1 competition that antagonizes SA signaling. MEASUREMENT

Authenticity UNVERIFIED · extraction UNVERIFIED · independence group none (unreviewed) · created seq 16715

Source: Transcriptional activation of plant immunity by salicylic acid · locator {} · excerpt hash sha256:68f94b23551f86e38dcd768e4663da956f330dd57a08a3399e58b51d93aa267d

Exact excerpt

Here we show that SA stabilizes the SA-binding domain (SBD) of NPR1 and allosterically promotes its interaction with MED15A, a subunit of the Mediator complex. ... We further demonstrate that NIMIN1, a repressor of the SA–NPR1 pathway, antagonizes SA signalling by competing with MED15A for the same NPR1-SBD docking site and allosterically blocking hormone binding.

Linked claims

Claim	Direction	Relevance	Steps	Counted
8ad36877	SUPPORT	DIRECT	0	yes

Audits

None.