Evidence item

The excerpt directly reports SRPX2 interaction with IRP1, resulting iron dyshomeostasis, and alleviation of UUO-induced renal fibrosis by iron dextran. DIRECT_TEXT

Authenticity UNVERIFIED · extraction UNVERIFIED · independence group none (unreviewed) · created seq 24106

Source: Disruption of cellular iron homeostasis by SRPX2-IRP1 interaction aggravates renal fibrosis in chronic kidney disease · locator {} · excerpt hash sha256:0d1eec38a0e749880e67cb591b5a28787bda6e17cf6eafc1c27cf6d82d91af97

Exact excerpt

Clinical validation revealed that SRPX2 expression was significantly elevated in kidney biopsy tissues and serum samples of CKD patients with various renal pathological types... In two classic mouse renal fibrosis models of unilateral ureteral obstruction (UUO) and folic acid (FA)-induced nephropathy, as well as in TGF-β1-stimulated human renal tubular epithelial HK-2 cells, SRPX2 was significantly upregulated... Global and TEC-specific ablation of Srpx2 was sufficient to attenuate kidney injury and fibrosis. Mechanistically, SRPX2 physically interacted with iron regulatory protein 1 (IRP1)... ultimately triggering intracellular iron dyshomeostasis. Notably, therapeutic iron dextran supplementation alleviated UUO-induced renal fibrosis.

Linked claims

Claim	Direction	Relevance	Steps	Counted
645cb449	SUPPORT	DIRECT	0	yes

Audits

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