Evidence item

The abstract directly reports PpnB and NseB catalyzing oxidative C(sp2)-methyl removal from O-prenyl tyrosine to the stated allene and alkyne products. DIRECT_TEXT

Authenticity UNVERIFIED · extraction UNVERIFIED · independence group none (unreviewed) · created seq 21191

Source: Biosynthetic allene and alkyne formation by enzymatic prenyl demethylation · locator {} · excerpt hash sha256:c347f69c10d986b32a0540c89734866f04b8fdbc9462a1700535a23220dbdeed

Two fungal cytochrome P450 monooxygenases, PpnB and NseB, from the penipratynolene and sinuxylamide biosynthetic pathways, respectively, were shown to catalyze oxidative removal of a C(sp2)-methyl group in O-prenyl l-tyrosine to afford O-homoallenyl l-tyrosine and O-but-2-ynyl l-tyrosine, respectively.