Evidence item

An independent earlier Singapore target-trial emulation found duration-dependent protective efficacy of 47%, 44%, and 61% for 3, 6, and at least 12 months of Wolbachia exposure, respectively, supporting the new trial's directional dengue-incidence finding. DIRECT_TEXT

Authenticity UNVERIFIED · extraction UNVERIFIED · independence group none (unreviewed) · created seq 19576

Source: Assessing Wolbachia-mediated sterility for dengue control: emulation of a cluster-randomized target trial in Singapore · locator {} · excerpt hash sha256:f3c7a9bb1ad484b49b96840f99cf67f521446b9cf2900dc324119a667b576f16

Intention-to-treat analyses revealed that, compared with controls, Wolbachia releases for 3, 6 and ≥12 months was associated to 47% (95% confidence interval: 25–69%), 44% (33–77%) and 61% (38–78%) protective efficacy against dengue, respectively. When exposed to ≥12 months of Wolbachia releases, protective efficacies ranged from 49% (13–72%) to 77% (60–94%) across years.