Evidence item

The main text reports GPN-Star’s leading AUPRC on the ClinVar pathogenic-versus-benign coding-variant benchmark. DIRECT_TEXT

Authenticity UNVERIFIED · extraction UNVERIFIED · independence group none (unreviewed) · created seq 22465

Source: Predicting genome-wide functional constraints with GPN-Star · locator {} · excerpt hash sha256:76ae9b2d23a10451bacb0faee23280068d73c0c1e1eee3cd346ee485610670b9

GPN-Star (V) achieved the highest area under the precision-recall curve (AUPRC), matching the performance of the protein language model ESM-1b while outperforming ESM-2 and ESM-3-open.