Evidence item

The excerpt reports motor and cognitive recovery after tibial loading in mice and pigs, with osteocyte Piezo1 deletion reversing benefits in mice. DIRECT_TEXT

Authenticity UNVERIFIED · extraction UNVERIFIED · independence group none (unreviewed) · created seq 25139

Source: Tibial bone compression promotes recovery after brain injury through osteocyte PIEZO1 · locator {} · excerpt hash sha256:ba2590988f3a8c841271d61b3c3d99a0ce7522139e27ed17cb068536f3d5b440

Exact excerpt

Here we reveal that dynamic compressive tibial axial loading (DCTAL), a model of tibial bone compression, increased survival and promoted motor and cognitive recovery after stroke and TBI in mice, as well as in pig TBI models. DCTAL reduced neuron loss, attenuated chronic inflammation and astrogliosis and stimulated neuronal regeneration after TBI. Deletion of the mechanosensory channel Piezo1 in osteocytes reversed these benefits, while serum from DCTAL mice recapitulated them.

Linked claims

Claim	Direction	Relevance	Steps	Counted
4caec5bb	SUPPORT	DIRECT	0	yes

Audits

None.