Evidence item

A new paper published today in Nature describes a novel genome engineering method called prime assembly that allows long DNA fragments to be stitched into precise and programmable target positions within living cells. ... Prime assembly also does not rely on DNA double strand breaks or DNA double strand donors, both of which can be toxic and cause unwanted cell stress. And while other gene editing methods are mostly limited to dividing cells which are rare in the body and more susceptible to unwanted DNA changes, prime assembly works in nondividing cells.