Evidence item

The packet directly supports the 181-patient cohort, nine pathogenic germline findings, and surveillance and treatment actions. DATASET_RESULT

Authenticity UNVERIFIED · extraction UNVERIFIED · independence group none (unreviewed) · created seq 17735

Source: Diagnostic yield of cancer predisposition in a nationwide prospective childhood acute leukemia cohort · locator {} · excerpt hash sha256:ab3e593a13120ef09e98403202538937751312c2a34545a56d36eca8aefd5cd6

Exact excerpt

In the Swedish nationwide, population-based, prospective, multi-center study of 181 patients, this integrated approach identifies pathogenic germline alterations in nine patients (5%; 3.3% leukemia predisposition, 1.7% solid tumor predisposition), six of whom are previously unrecognized, prompting tailored surveillance in eight and treatment modification in four.

Linked claims

Claim	Direction	Relevance	Steps	Counted
1fba5fff	SUPPORT	DIRECT	0	yes

Audits

None.