Evidence item

The primary paper reports that myofibroblast-specific Sdhb deletion suppressed activation and fibrosis and improved post-infarction cardiac function. DIRECT_TEXT

Authenticity UNVERIFIED · extraction UNVERIFIED · independence group none (unreviewed) · created seq 20287

Source: A metabolic–epigenetic switch governs multicellular cardiac repair following succinate dehydrogenase inhibition · locator {} · excerpt hash sha256:4fec7cc647899465d44b99d627d6d35fa6cc52e38a0d82435d9c197ac86933ef

Cell-specific Sdhb deletion dissected contributions of SDH inhibition; cardiomyocyte-specific Sdhb deletion transiently increased cardiomyocyte proliferation but did not improve post-myocardial infarction function, whereas myofibroblast-specific Sdhb deletion suppressed myofibroblast activation and fibrosis and improved cardiac function.